Evidence map›Paper›PMID 28605895›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2017

Hydrogel Patches on Live Cells through Surface-Mediated Polymerization.

Pei-Jung Wu, Jacob L Lilly, Roberto Arreaza, Brad J Berron

Abstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Increased yield of gelatin coated therapeutic cells through cholesterol insertion.Journal of biomedical materials research. Part A · 2021
    Article
  3. Article
  4. Article
  5. Ionic Hydrogel for Accelerated Dopamine Delivery via Retrodialysis.Chemistry of materials : a publication of the American Chemical Society · 2019
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pei-Jung WuChemical and Materials Engineering, University of Kentucky , 153 FPAT, Lexington, Kentucky 40506-0046, United States.ORCID 0000-0002-9929-5704
Jacob L LillyChemical and Materials Engineering, University of Kentucky , 153 FPAT, Lexington, Kentucky 40506-0046, United States.
Roberto ArreazaChemical and Materials Engineering, University of Kentucky , 153 FPAT, Lexington, Kentucky 40506-0046, United States.
Brad J BerronChemical and Materials Engineering, University of Kentucky , 153 FPAT, Lexington, Kentucky 40506-0046, United States.

Funding

Specific Lysis for Large-Volume, High-Purity Endothelial Progenitor Cell IsolatesR01HL127682 · NHLBI · UNIVERSITY OF KENTUCKY · PI BERRON, BRADLEY JOSEPH · 2015 to 2018
$2.3M
NHLBI NIH HHS R01 HL127682
6 · The paper itself

Abstract

Many naturally occurring cells possess an intrinsic ability to cross biological barriers that block conventional drug delivery, and these cells offer a possible mode of active transport across the blood-brain barrier or into the core of tumor masses. While many technologies for the formation of complete, nanoparticle-loaded coatings on cells exist, a complete coating on the cell surface would disrupt the interaction of cells with their environments. To address this issue, cell surface patches that partially cover cell surfaces might provide a superior approach for cell-mediated therapeutic delivery. The goal of this study is to establish a simplified approach to producing polymeric patches of arbitrary shapes on a live cell via surface-mediated photopolymerization. Cell surfaces were nonspecifically labeled with eosin, and polyethylene (glycol) diacrylate (PEGDA) coatings were directed to specific sites using 530 nm irradiation through a chrome-coated photomask. These coatings may entrap drug-loaded or imaging particles. The extent of nonspecific formation of PEGDA hydrogel coatings increased with irradiation time, light intensity, and initiating species; 40 mW/cm

Indexed as

AnimalsCell SurvivalHumansHydrogelsPolyethylene GlycolsPolymerizationRatsSerum Albumin, BovineHydrogelsPolyethylene GlycolsSerum Albumin, Bovine

Identifiers

PMID28605895
PMCPMC5541780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.