Evidence map›Paper›PMID 28605638›Full record

ReviewCurrent opinion in biotechnology2017

Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells.

Kristen A Lemke, Alireza Aghayee, Randolph S Ashton

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Physiomimetic Models of Adenomyosis.Seminars in reproductive medicine · 2020
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristen A LemkeWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53706, United States.
Alireza AghayeeWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53706, United States; Department of Material Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, United States.
Randolph S AshtonWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53706, United States; Department of Material Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, United States; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, United States. Electronic address: rashton2@wisc.edu.

Funding

High-Throughput Modeling of ALS Using iPSC-Derived Neural Tube MicroarraysR33NS082618 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ASHTON, RANDOLPH S · 2017 to 2018
$779k
High-Throughput Modeling of ALS Using iPSC-Derived Neural Tube MicroarraysR21NS082618 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ASHTON, RANDOLPH S · 2014 to 2015
$348k
NINDS NIH HHS R21 NS082618NINDS NIH HHS R33 NS082618
6 · The paper itself

Abstract

Progress in deriving a spectrum of central nervous system cell phenotypes from human pluripotent stem cells has spurred significant advances in in vitro modeling and development of regenerative therapies for neurological disorders. While the clinical impact of these advances is still being evaluated, their integration with advanced tissue engineering methodologies and therapeutic approaches that induce neural circuit plasticity, respectively, remain underexplored frontiers.

Indexed as

HumansPhenotypePluripotent Stem CellsRegenerationSignal TransductionTissue Engineering

Identifiers

PMID28605638
PMCPMC5617772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.