Evidence map›Paper›PMID 28605504›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017

Projecting 10-year, 20-year, and Lifetime Risks of Cardiovascular Disease in Persons Living With Human Immunodeficiency Virus in the United States.

Elena Losina, Emily P Hyle, Ethan D Borre, Benjamin P Linas, Paul E Sax, Milton C Weinstein, Corinna Rusu, Andrea L Ciaranello, Rochelle P Walensky, Kenneth A Freedberg

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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  20. Cardiovascular disease risk in women living with HIV.Current opinion in HIV and AIDS · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena LosinaCenter for AIDS Research, Harvard University, MA.
Emily P HyleThe Medical Practice Evaluation Center, Massachusetts General Hospital.
Ethan D BorreThe Medical Practice Evaluation Center, Massachusetts General Hospital.
Benjamin P LinasCenter for AIDS Research, Brown-Boston University.
Paul E SaxCenter for AIDS Research, Harvard University, MA.
Milton C WeinsteinDepartment of Health Policy and Management, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Corinna RusuThe Medical Practice Evaluation Center, Massachusetts General Hospital.
Andrea L CiaranelloCenter for AIDS Research, Harvard University, MA.
Rochelle P WalenskyCenter for AIDS Research, Harvard University, MA.
Kenneth A FreedbergCenter for AIDS Research, Harvard University, MA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
Utilization of health services after engagement with opioid use disorder (OUD) treatment provider by individuals with and without post-traumatic stress disorderP30DA040500 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Yuhua Bao · 2015 to 2026
$20.7M
Development and application of a new simulation model for COVID-19R01AI042006 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Anne Neilan · 1998 to 2026
$12.9M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Cardiovascular Disease in South African HIV Patients: Value of PreventionK01HL123349 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HYLE, EMILY PARKER · 2016 to 2020
$896k
NHLBI NIH HHS K01 HL123349NIAID NIH HHS P30 AI042853NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI042006NIAID NIH HHS T32 AI007433NIDA NIH HHS P30 DA040500NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Background: Cardiovascular disease (CVD) is an increasing cause of morbidity among persons living with human immunodeficiency virus (HIV; PLWH). We projected cumulative CVD risk in PLWH in care compared to the US general population and persons HIV-uninfected, but at high risk for HIV. Methods: We used a mathematical model to project cumulative CVD incidence. We simulated a male and female cohort for each of 3 populations: US general population; HIV-uninfected, at high risk for HIV; and PLWH. We incorporated the higher smoking prevalence and increased CVD risk due to smoking into the HIV-infected and HIV-uninfected, at high risk for HIV populations. We incorporated HIV-attributable CVD risk, independent of smoking. Results: For men, life expectancy ranged from 70.2 to 77.5 years and for women from 67.0 to 81.1 years (PLWH, US general population). Without antiretroviral therapy, lifetime CVD risk for HIV-infected males and females was 12.9% and 9.0%. For males, by age 60, cumulative CVD incidence was estimated at 20.5% in PLWH in care, 14.6% in HIV-uninfected high-risk persons, and 12.8% in the US general population. For females, cumulative CVD incidence was projected to be 13.8% in PLWH in care, 9.7% for high-risk HIV-uninfected persons, and 9.4% in the US general population. Lifetime CVD risk was 64.8% for HIV-infected males compared to 54.8% for males in the US general population, but similar among females. Conclusions: CVD risks should be a part of treatment evaluation among PLWH. CVD prevention strategies could offer important health benefits for PLWH and should be evaluated.

Indexed as

AdultAgedCardiovascular DiseasesFemaleHIV InfectionsHumansIncidenceLife ExpectancyMaleMiddle AgedModels, StatisticalRisk FactorsSmokingYoung Adultcardiovascular diseaseHIV/AIDSlifetime risk

Identifiers

PMID28605504
PMCPMC5850036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.