Evidence map›Paper›PMID 28605409›Full record

ArticleCarcinogenesis2017

Hair product use and breast cancer risk among African American and White women.

Adana A M Llanos, Anna Rabkin, Elisa V Bandera, Gary Zirpoli, Brian D Gonzalez, Cathleen Y Xing, Bo Qin, Yong Lin, Chi-Chen Hong, Kitaw Demissie and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Adana A M LlanosDepartment of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Anna RabkinDepartment of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Elisa V BanderaDepartment of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Gary ZirpoliDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Brian D GonzalezCancer Prevention and Control Program, Division of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Cathleen Y XingDepartment of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Bo QinCancer Prevention and Control Program, Division of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Yong LinDepartment of Biostatistics, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Chi-Chen HongDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Kitaw DemissieDepartment of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Christine B AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Rutgers Cancer Institute of New JerseyRoswell Park Comprehensive Cancer Center · USRutgers, The State University of New Jersey · USJohnson University · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
Reproduction, Lactation and Hormonal Factors in Breast Cancer SubtypesP01CA151135 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B., OLSHAN, ANDREW · 2011 to 2017
$18.1M
Obesity, related comorbidities, and breast cancer outcomes in African AmericansR01CA185623 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI BANDERA, ELISA V, DEMISSIE, KITAW · 2014 to 2018
$6.2M
Race &Risk Factors for Early/Aggressive Breast CancerR01CA100598 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B. · 2004 to 2008
$4.8M
Adipokines, adipokine receptors, and disparities in breast cancer clinicopathological featuresK01CA193527 · NCI · RBHS-SCHOOL OF PUBLIC HEALTH · PI LLANOS, ADANA A. M. · 2015 to 2020
$692k
Developing a Culturally Targeted mHealth Intervention for Cancer-Related Sleep Disturbance in African American Breast Cancer SurvivorsK01CA211789 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI GONZALEZ, BRIAN D · 2016 to 2019
$585k
NCI NIH HHS K01 CA193527NCI NIH HHS K01 CA211789NCI NIH HHS P01 CA151135NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA100598NCI NIH HHS R01 CA185623
6 · The paper itself

Abstract

Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined hair product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) and White women, and explored associations with breast cancer. Multivariable-adjusted models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to describe the associations of interest among 2280 cases (1508 AA and 772 White) and 2005 controls (1290 AA and 715 White). Among controls, hair dye use was more common among Whites than AAs (58 versus 30%), while relaxer (88 versus 5%) and deep conditioner use (59 versus 6%) was more common among AAs. Among AAs, use of dark hair dye shades was associated with increased breast cancer risk (OR = 1.51, 95% CI: 1.20-1.90) and use of dark shades (OR = 1.72, 95% CI: 1.30-2.26) and higher frequency of use (OR = 1.36, 95% CI: 1.01-1.84) were associated with ER+ disease. Among Whites, relaxer use (OR = 1.74, 95% CI: 1.11-2.74) and dual use of relaxers and hair dyes (OR = 2.40, 95% CI: 1.35-4.27) was associated with breast cancer; use of dark hair dyes was associated with increased ER+ disease (OR = 1.54, 95% CI: 1.01-2.33), and relaxer use was associated with increased ER- disease (OR = 2.56, 95% CI: 1.06-6.16). These novel findings provide support a relationship between the use of some hair products and breast cancer. Further examinations of hair products as important exposures contributing to breast cancer carcinogenesis are necessary.

Indexed as

AdultAgedBlack or African AmericanBreast NeoplasmsCase-Control StudiesFemaleHair PreparationsHumansMiddle AgedNew JerseyNew York CityOdds RatioPrevalenceReceptors, EstrogenRisk FactorsSurveys and QuestionnairesHair PreparationsReceptors, Estrogen

Identifiers

PMID28605409
PMCPMC5862263
OpenAlexW2621921829

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.