Evidence map›Paper›PMID 28605050›Full record

ArticleScandinavian journal of immunology2017

The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.

S Ganesan, T T Luu, B J Chambers, S Meinke, P Brodin, E Vivier, D M Wetzel, A J Koleske, N Kadri, P Höglund

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

S GanesanCenter for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
T T LuuCenter for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
B J ChambersDepartment of Medicine, Center for Infectious Medicine, F59, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0437-8441
S MeinkeCenter for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
P BrodinScience for Life Laboratory, Department of Medicine Solna, Karolinska Institutet and Department of Neonatology, Karolinska Institutet and Department of Neonatology, Karolinska university Hospital, Stockholm, Sweden.
E VivierCentre d'Immunologie de Marseille-Luminy, Université Aix-Marseille UM2, INSERM, U1104, CNRS UMR 7258, Marseille, France.
D M WetzelDepartment of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
A J KoleskeImmunologie, Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
N KadriCenter for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
P HöglundCenter for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-9233-626X
Karolinska Institutet · SEKarolinska University Hospital · SEAix-Marseille Université · FRCentre National de la Recherche Scientifique · FRThe University of Texas Southwestern Medical Center · US

Funding

Research Training in Pediatric Infectious DiseasesT32AI007210 · NIAID · YALE UNIVERSITY · PI MURRAY, THOMAS SCOT, SHAPIRO, EUGENE DAVID · 1986 to 2023
$2.6M
Supplement to Regulation of invadopodia formation in breast cancer cellsR01CA133346 · NCI · YALE UNIVERSITY · PI KOLESKE, ANTHONY J · 2009 to 2016
$2.3M
Laminin control of CNS dendrite and dendritic spine developmentR01NS089662 · NINDS · YALE UNIVERSITY · PI GRUTZENDLER, JAIME, KOLESKE, ANTHONY J · 2014 to 2018
$1.8M
Targeting Entry Pathways in LeishmaniasisK08AI103036 · NIAID · YALE UNIVERSITY · PI WETZEL, DAWN MARIE · 2013 to 2015
$397k
Cytoskeletal control of Leishmania infectionF32AI094905 · NIAID · YALE UNIVERSITY · PI WETZEL, DAWN MARIE · 2011 to 2012
$100k
NCI NIH HHS R01 CA133346NIAID NIH HHS F32 AI094905NIAID NIH HHS K08 AI103036NIAID NIH HHS T32 AI007210NINDS NIH HHS R01 NS089662
6 · The paper itself

Abstract

Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signalling in human NK cells involves Abl-1 (c-Abl)-mediated phosphorylation of Crk, lowering NK cell function via disruption of a signalling complex including C3G and c-Cbl, suggesting that NK cell education might involve c-Abl. Mice deficient in c-Abl expression specifically in murine NK cells displayed normal inhibitory and activating receptor repertoires. Furthermore, c-Abl-deficient NK cells fluxed Ca

Indexed as

Cell DifferentiationLymphocyte ActivationSignal TransductionAnimalsAntigens, LyCells, CulturedCytotoxicity, ImmunologicImmunity, InnateInterferon-gammaKiller Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutNatural Cytotoxicity Triggering Receptor 1NK Cell Lectin-Like Receptor Subfamily CProto-Oncogene Proteins c-ablAntigens, LyInterferon-gammaNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseNK Cell Lectin-Like Receptor Subfamily CProto-Oncogene Proteins c-abl

Identifiers

PMID28605050
PMCPMC5568956
OpenAlexW2625483683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.