Evidence map›Paper›PMID 28604925›Full record

ArticleJAMA internal medicine2017

Association of Adverse Events With Antibiotic Use in Hospitalized Patients.

Pranita D Tamma, Edina Avdic, David X Li, Kathryn Dzintars, Sara E Cosgrove

4 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 400 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
400citing papers in PubMed, 12 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04089787 phase4completednot on this mapstarted 2019, after this paper: background citation

Shortened Antibiotic Treatment in Community-Acquired Pneumonia: A Nationwide Danish Randomized Controlled Trial

TypeinterventionalSponsorThomas BenfieldRan2019 to 2025Enrolled395ConditionsCommunity-acquired PneumoniaArmsIntervention, Control
NCT04291768 phase4recruitingnot on this mapstarted 2020, after this paper: background citation

Short Course Antibiotic Treatment of Gram-negative Bacteremia: A Multicenter, Randomized, Non-blinded, Non-inferiority Interventional Study

TypeinterventionalSponsorThomas BenfieldRan2020 to 2026Enrolled380ConditionsGram-negative Bacteremia, Urinary Tract Infection BacterialArmsShortened antibiotic treatment, Standard antibiotic treatment
NCT05762302 narecruitingnot on this mapstarted 2023, after this paper: background citation

A Multicenter Randomized Controlled Trial to Establish the Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)

TypeinterventionalSponsorMeMed Diagnostics Ltd.Ran2023 to 2026Enrolled1,316ConditionsLower Respiratory Tract InfectionArmsMeMed BV test
NCT05975671 narecruitingnot on this mapstarted 2023, after this paper: background citation

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2023 to 2026Enrolled52,500ConditionsSepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced NephropathyArmsMultifaceted de-implementation strategy to reduce vancomycin overuse
3 · Its place in the literature

Who cites it

400 citing papers in PubMed, 12 syntheses or guidelines pooled it, 745 citations in OpenAlex.

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  3. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Guideline
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340 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pranita D TammaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Edina AvdicDepartment of Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland.
David X LiDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kathryn DzintarsDepartment of Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland.
Sara E CosgroveDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USJohns Hopkins Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Estimates of the incidence of overall antibiotic-associated adverse drug events (ADEs) in hospitalized patients are generally unavailable. Objective: To describe the incidence of antibiotic-associated ADEs for adult inpatients receiving systemic antibiotic therapy. Design, Setting, and Participants: Retrospective cohort of adult inpatients admitted to general medicine wards at an academic medical center. Exposures: At least 24 hours of any parenteral or oral antibiotic therapy. Main Outcomes and Measures: Medical records of 1488 patients were examined for 30 days after antibiotic initiation for the development of the following antibiotic-associated ADEs: gastrointestinal, dermatologic, musculoskeletal, hematologic, hepatobiliary, renal, cardiac, and neurologic; and 90 days for the development of Clostridium difficile infection or incident multidrug-resistant organism infection, based on adjudication by 2 infectious diseases trained clinicians. Results: In 1488 patients, the median age was 59 years (interquartile range, 49-69 years), and 758 (51%) participants were female. A total of 298 (20%) patients experienced at least 1 antibiotic-associated ADE. Furthermore, 56 (20%) non-clinically indicated antibiotic regimens were associated with an ADE, including 7 cases of C difficile infection. Every additional 10 days of antibiotic therapy conferred a 3% increased risk of an ADE. The most common ADEs were gastrointestinal, renal, and hematologic abnormalities, accounting for 78 (42%), 45 (24%), and 28 (15%) 30-day ADEs, respectively. Notable differences were identified between the incidence of ADEs associated with specific antibiotics. Conclusions and Relevance: Although antibiotics may play a critical role when used appropriately, our findings underscore the importance of judicious antibiotic prescribing to reduce the harm that can result from antibiotic-associated ADEs.

Indexed as

Anti-Bacterial AgentsDrug-Related Side Effects and Adverse ReactionsAdverse Drug Reaction Reporting SystemsAgedDrug Administration RoutesFemaleHospitalizationHumansIncidenceInpatientsMaleMedical OveruseMiddle AgedNeeds AssessmentPatients' RoomsPractice Patterns, Physicians'Anti-Bacterial Agents

Identifiers

PMID28604925
PMCPMC5710569
OpenAlexW2627012798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.