ArticlePloS one2017
Tinnitus alters resting state functional connectivity (RSFC) in human auditory and non-auditory brain regions as measured by functional near-infrared spectroscopy (fNIRS).
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Enhanced classification of tinnitus patients using EEG microstates and deep learning techniques.Scientific reports · 2025Article
- A narrative review of functional near-infrared spectroscopy (fNIRS) applications in hearing loss, tinnitus and vestibular disorders.Frontiers in neuroscience · 2025Review
- Predicting Individual Response to Acupuncture in Sensorineural Tinnitus Using Integrated Functional Near-Infrared Spectroscopy and Machine Learning: Protocol for a Model Development and Validation Study.Journal of multidisciplinary healthcare · 2025Article
- Exploring the interplay of depression, sleep quality, and hearing in tinnitus-related handicap: insights from polysomnography and pure-tone audiometry.BMC psychiatry · 2024Article
- Functional Near-Infrared Spectroscopy in neurodegenerative disease: a review.Frontiers in neuroscience · 2024Review
- Application of functional near-infrared spectroscopy (fNIRS) in tinnitus research: contemporary insights and perspectives.Frontiers in psychology · 2024Article
- Review
- Controlling jaw-related motion artifacts in functional near-infrared spectroscopy.Journal of neuroscience methods · 2023Article
- Evaluating the Efficacy and Underlying Mechanisms of Acupuncture for Chronic Subjective Tinnitus Using Functional Near-Infrared Spectroscopy: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2023Article
- Tinnitus and auditory cortex; Using adapted functional near-infrared-spectroscopy to expand brain imaging in humans.Laryngoscope investigative otolaryngology · 2021Article
- Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity.Neuroreport · 2021Article
- Notched Sound Alleviates Tinnitus by Reorganization Emotional Center.Frontiers in human neuroscience · 2021Article
- Tinnitus Update.Journal of clinical neurology (Seoul, Korea) · 2021Review
- Cortical Activation Patterns of Different Masking Noises and Correlation With Their Masking Efficacy, Determined by Functional Near-Infrared Spectroscopy.Frontiers in human neuroscience · 2020Article
- Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning.PloS one · 2020Article
- Functional Near-Infrared Spectroscopy to Probe tDCS-Induced Cortical Functioning Changes in Tinnitus.The journal of international advanced otology · 2019Article
- Human central auditory plasticity: A review of functional near-infrared spectroscopy (fNIRS) to measure cochlear implant performance and tinnitus perception.Laryngoscope investigative otolaryngology · 2018Review
- Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network.Neuropsychiatric disease and treatment · 2018Article
- Commentary: Comparison of the Long-Term Effect of Positioning the Cathode in tDCS in Tinnitus Patients.Frontiers in aging neuroscience · 2017Article
- The Pathological Mechanisms and Treatments of Tinnitus.Discoveries (Craiova, Romania)Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus, or phantom sound perception, leads to increased spontaneous neural firing rates and enhanced synchrony in central auditory circuits in animal models. These putative physiologic correlates of tinnitus to date have not been well translated in the brain of the human tinnitus sufferer. Using functional near-infrared spectroscopy (fNIRS) we recently showed that tinnitus in humans leads to maintained hemodynamic activity in auditory and adjacent, non-auditory cortices. Here we used fNIRS technology to investigate changes in resting state functional connectivity between human auditory and non-auditory brain regions in normal-hearing, bilateral subjective tinnitus and controls before and after auditory stimulation. Hemodynamic activity was monitored over the region of interest (primary auditory cortex) and non-region of interest (adjacent non-auditory cortices) and functional brain connectivity was measured during a 60-second baseline/period of silence before and after a passive auditory challenge consisting of alternating pure tones (750 and 8000Hz), broadband noise and silence. Functional connectivity was measured between all channel-pairs. Prior to stimulation, connectivity of the region of interest to the temporal and fronto-temporal region was decreased in tinnitus participants compared to controls. Overall, connectivity in tinnitus was differentially altered as compared to controls following sound stimulation. Enhanced connectivity was seen in both auditory and non-auditory regions in the tinnitus brain, while controls showed a decrease in connectivity following sound stimulation. In tinnitus, the strength of connectivity was increased between auditory cortex and fronto-temporal, fronto-parietal, temporal, occipito-temporal and occipital cortices. Together these data suggest that central auditory and non-auditory brain regions are modified in tinnitus and that resting functional connectivity measured by fNIRS technology may contribute to conscious phantom sound perception and potentially serve as an objective measure of central neural pathology.
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