ArticlePLoS genetics2017
The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed.
- The Plant Cell Wall: From Structural Diversity and Biosynthesis to Integrity Signaling and Physiological Functions.Plants (Basel, Switzerland) · 2026Review
- A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor.The New phytologist · 2026Article
- Small Peptides, Smart Plants: The Emerging Significance of SCOOP Signalling.Plant, cell & environment · 2026Review
- A STRUBBELIG-NHL3 cell surface receptor complex mediates the response to cellulose deficiency in Arabidopsis.Nature plants · 2026Article
- A molecular description of plant cellulose biosynthesis inhibition.bioRxiv : the preprint server for biology · 2026Article
- COMPOSITUM 2/ WHEAT FRIZZY PANICLE dosage dependently regulates inflorescence and root architecture in Triticeae cereals.The Plant journal : for cell and molecular biology · 2026Article
- Advances in the roles of SCOOP peptides and the receptor-like kinase MIK2 in plant stress responses.Plant cell reports · 2026Review
- Plant cell wall remodeling and peptide signaling under abiotic and biotic stress.Plant communications · 2026Review
- Cooperative siderophore use stabilizes a protective leaf microbiome.bioRxiv : the preprint server for biology · 2026Article
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
- The Arabidopsis phosphatase PP2C12 negatively regulates LRX-RALF-FER-mediated cell wall integrity sensing.The EMBO journal · 2026Article
- The function of the Arabidopsis receptor kinase THESEUS1 in plant cell wall integrity maintenance: from evolutionary origin to future perspectives.The Plant journal : for cell and molecular biology · 2026Review
- Memory in the wall: expanding our understanding of the roles of plant cell walls.The New phytologist · 2026Review
- Genetic mapping reveals QTLs associated with HLB response determined byFrontiers in plant science · 2026Article
- Targeting calcineurin: a synergistic strategy with caspofungin to induce farnesol-mediated quorum sensing in Nakaseomyces glabrata-an inoculum-dependent tale.The Biochemical journal · 2025Article
- Deciphering the Sodium Sensing Mechanisms in Glycophytes and Halophytes.Plant, cell & environment · 2025Review
- Promiscuity and specificity in ligand sensing by plant cell surface receptors.PLoS pathogens · 2025Article
- Chromosome-level genome assembly ofPlant diversity · 2025Article
- Mechanical stimulation in plants: molecular insights, morphological adaptations, and agricultural applications in monocots.BMC biology · 2025Review
- Pattern Recognition Receptors in Plant Immunity.Advances in experimental medicine and biology · 2025Review
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
Plants actively perceive and respond to perturbations in their cell walls which arise during growth, biotic and abiotic stresses. However, few components involved in plant cell wall integrity sensing have been described to date. Using a reverse-genetic approach, we identified the Arabidopsis thaliana leucine-rich repeat receptor kinase MIK2 as an important regulator of cell wall damage responses triggered upon cellulose biosynthesis inhibition. Indeed, loss-of-function mik2 alleles are strongly affected in immune marker gene expression, jasmonic acid production and lignin deposition. MIK2 has both overlapping and distinct functions with THE1, a malectin-like receptor kinase previously proposed as cell wall integrity sensor. In addition, mik2 mutant plants exhibit enhanced leftward root skewing when grown on vertical plates. Notably, natural variation in MIK2 (also named LRR-KISS) has been correlated recently to mild salt stress tolerance, which we could confirm using our insertional alleles. Strikingly, both the increased root skewing and salt stress sensitivity phenotypes observed in the mik2 mutant are dependent on THE1. Finally, we found that MIK2 is required for resistance to the fungal root pathogen Fusarium oxysporum. Together, our data identify MIK2 as a novel component in cell wall integrity sensing and suggest that MIK2 is a nexus linking cell wall integrity sensing to growth and environmental cues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.