ArticlePLoS genetics2017
Lokiarchaea are close relatives of Euryarchaeota, not bridging the gap between prokaryotes and eukaryotes.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Diversity, ecology, cell biology and evolution of the Asgard archaea.Nature reviews. Microbiology · 2026Review
- The archaeal roots of eukaryotic life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reassessing viral origins and evolutionary placement in the tree of life.Antonie van Leeuwenhoek · 2026Review
- Phylogeny Building for Structural Phylogenomic Research.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Evolutionary Reasoning Does Not Arise in Standard Usage of Protein Language Models.bioRxiv : the preprint server for biology · 2025Article
- Bioenergetics evolution: the link between Earth's and Life's history.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Review
- Candidatus List No. 6.International journal of systematic and evolutionary microbiology · 2025Article
- Article
- When the Past Fades: Detecting Phylogenetic Signal with SatuTe.Molecular biology and evolution · 2025Article
- Article
- RNA-Binding S1 Domain in Bacterial, Archaeal and Eukaryotic Proteins as One of the Evolutionary Markers of Symbiogenesis.International journal of molecular sciences · 2024Article
- The Last Universal Common Ancestor of Ribosome-Encoding Organisms: Portrait of LUCA.Journal of molecular evolution · 2024Review
- Review
- The dynamic history of prokaryotic phyla: discovery, diversity and division.International journal of systematic and evolutionary microbiology · 2024Review
- Protein structures unravel the signatures and patterns of deep time evolution.QRB discovery · 2024Review
- Fast-Evolving Alignment Sites Are Highly Informative for Reconstructions of Deep Tree of Life Phylogenies.Microorganisms · 2023Article
- Article
- Ribosomal Protein Cluster Organization in Asgard Archaea.Archaea (Vancouver, B.C.) · 2023Article
34 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The eocyte hypothesis, in which Eukarya emerged from within Archaea, has been boosted by the description of a new candidate archaeal phylum, "Lokiarchaeota", from metagenomic data. Eukarya branch within Lokiarchaeota in a tree reconstructed from the concatenation of 36 universal proteins. However, individual phylogenies revealed that lokiarchaeal proteins sequences have different evolutionary histories. The individual markers phylogenies revealed at least two subsets of proteins, either supporting the Woese or the Eocyte tree of life. Strikingly, removal of a single protein, the elongation factor EF2, is sufficient to break the Eukaryotes-Lokiarchaea affiliation. Our analysis suggests that the three lokiarchaeal EF2 proteins have a chimeric organization that could be due to contamination and/or homologous recombination with patches of eukaryotic sequences. A robust phylogenetic analysis of RNA polymerases with a new dataset indicates that Lokiarchaeota and related phyla of the Asgard superphylum are sister group to Euryarchaeota, not to Eukarya, and supports the monophyly of Archaea with their rooting in the branch leading to Thaumarchaeota.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.