Observational studyPediatric research2017
Markers of maternal and infant metabolism are associated with ventricular dysfunction in infants of obese women with type 2 diabetes.
Observational study in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Prognostic Impact of Pregnancy-Associated Plasma Protein-A (PAPP-A) for Gestational Diabetes Mellitus (GDM): An Updated Systematic Review and Meta-Analysis of More Than 90 000 Pregnancies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Pooled it
- Pooled it
- Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Pooled it
- Pilot Randomized Controlled Trial of Diabetes Group Prenatal Care.American journal of perinatology · 2022Trial
- Cardiac function in newborns of obese women and the effect of exercise during pregnancy. A randomized controlled trial.PloS one · 2018Trial
- Exploring the associations of overweight and obesity with pregnancy outcomes in type 1 and type 2 diabetes: An Australian retrospective cohort study.Journal of diabetes investigation · 2026Article
- Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2026Article
- Evaluation of Changes in the Anthropometric Measurements of Infants in Relation to the Type of Feeding and the Presence of Gestational Diabetes in Their Mothers: A Preliminary Study.Journal of clinical medicine · 2025Article
- Echocardiographic Assessment of Biventricular Mechanics of Fetuses and Infants of Gestational Diabetic Mothers: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2024Review
- Evaluating the Impact of Maternal Lipid Profiles on Fetal Cardiac Function at Mid-Gestation: An Observational Study.Clinics and practice · 2024Article
- Changes in the shape and function of the fetal heart of pre- and gestational diabetes mothers.BMC pregnancy and childbirth · 2024Article
- Impaired myocardial deformation persists at 2 years in offspring of mothers with diabetes mellitus.Pediatric research · 2023Observational
- Incidence of Fetal Myocardial Hypertrophy in Mother with Diabetes Mellitus by Using Cardio-Spatiotemporal Image Correlation (STIC) M-Mode.International journal of women's health · 2023Article
- Comprehensive assessment of biventricular myocardial function by two-dimensional speckle tracking echocardiography in infants of gestational diabetic mothers.Acta diabetologica · 2022Article
- Impact of maternal diabetes and obesity on fetal cardiac functions.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2020Article
- Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring.International journal of obesity (2005) · 2020Article
- Cardiac mechanics in infants with Down syndrome in the early neonatal period.Journal of perinatology : official journal of the California Perinatal Association · 2019Observational
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BackgroundTo test the hypothesis that infants born to obese women with pre-gestational type 2 diabetes mellitus (IBDMs) have ventricular dysfunction at 1 month that is associated with markers of maternal lipid and glucose metabolism.MethodsIn a prospective observational study of IBDMs (OB+DM, n=25), echocardiographic measures of septal, left (LV) and right ventricular (RV) function, and structure were compared at 1 month of age with those in infants born to OB mothers without DM (OB, n=24) and to infants born to non-OB mothers without DM (Lean, n=23). Basal maternal lipid and glucose kinetics and maternal plasma and infant (cord) plasma were collected for hormone and cytokine analyses.ResultsRV, LV, and septal strain measures were lower in the OB+DM infants compared with those in other groups, without evidence of septal hypertrophy. Maternal hepatic insulin sensitivity, maternal plasma free-fatty-acid concentration, and cord plasma insulin and leptin most strongly predicted decreased septal strain in OB+DM infants.ConclusionIBDMs have reduced septal function at 1 month in the absence of septal hypertrophy, which is associated with altered maternal and infant lipid and glucose metabolism. These findings suggest that maternal obesity and DM may have a prolonged impact on the cardiovascular health of their offspring, despite the resolution of cardiac hypertrophy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.