ArticlePediatric research2017
Physical exercise intervention at school improved hepcidin, inflammation, and iron metabolism in overweight and obese children and adolescents.
Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06387758 (Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease), which is not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Overnutrition is a risk factor for iron, but not for zinc or vitamin A deficiency in children and young people: a systematic review and meta-analysis.BMJ global health · 2024Pooled it
- The Effects of Football Practice on Nutritional Status and Body Composition in Children: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review.Jornal de pediatriaPooled it
- The Nutritional Paradox of Obesity: Mechanisms and Clinical Implications of Micronutrient Deficiencies.Medical sciences (Basel, Switzerland) · 2026Review
- The Interplay Between Iron Metabolism and Insulin Resistance: A Key Factor in Optimizing Obesity Management in Children and Adolescents.Nutrients · 2025Review
- High prevalence of anemia and overweight among women workers in three palm plantations in Indonesia: a cross sectional study.Journal of health, population, and nutrition · 2024Article
- Longitudinal reallocations of time between 24-h movement behaviours and their associations with inflammation in children and adolescents: the UP&DOWN study.The international journal of behavioral nutrition and physical activity · 2023Article
- Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial.Frontiers in nutrition · 2023Article
- Association between obesity and iron deficiency (Review).Experimental and therapeutic medicine · 2021Review
- Iron and zinc homeostases in female rats with physically active and sedentary lifestyles.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Impact of resistance training and basic ferritin on hepcidin, iron status and some inflammatory markers in overweight/obese girls.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.Journal of inflammation (London, England) · 2020Article
- Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundObesity is often associated with iron deficiency in children and adolescents. We aimed to study the effect of an 8-month physical exercise (PE) intervention on hepcidin and other markers of inflammation and on iron status in overweight/obese children and adolescents.MethodsSeventy-three overweight/obese children and adolescents participated in the 8-month-long longitudinal study. They were divided into two groups according to their participation in an after-school PE program: the PE group (n=44) and the control group (n=29). Hepcidin, interleukin (IL)-6, C-reactive protein (CRP), iron, ferritin, transferrin, and soluble transferrin receptor (sTfR) were evaluated.ResultsAt baseline, IL-6 correlated positively with hepcidin and negatively with iron and transferrin saturation, suggesting that increasing adiposity associates with increasing IL-6 and hepcidin synthesis, reducing iron availability. After 8 months, the PE group showed a decrease in BMI z-score (P=0.003), body fat mass (P=0.012), CRP (P=0.002), IL-6 (P=0.048), ferritin (P=0.013), hepcidin (P=0.040), and sTfR (P=0.010), and an increase in iron concentration (P=0.002). Moreover, the PE group, when compared with the control group, showed lower weight (P=0.026), BMI (P=0.040), waist circumference (P=0.010), and waist-to-height ratio (P=0.046).ConclusionWe showed that an 8-month-long intervention at school allowed a reduction in BMI z-score and an improvement in inflammation, reducing hepcidin levels and the disturbances in iron status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.