ReviewNature reviews. Immunology2017
How nutrition and the maternal microbiota shape the neonatal immune system.
Review in Nature reviews. Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
191 citing papers in PubMed, 4 syntheses or guidelines pooled it, 389 citations in OpenAlex.
- Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review.Developmental psychobiology · 2025Pooled it
- Association between antibiotic exposure and adverse outcomes of children and pregnant women: evidence from an umbrella review.World journal of pediatrics : WJP · 2023Pooled it
- The role of gut micorbiome in obesity and diabetes.World journal of pediatrics : WJP · 2019Pooled it
- Plasticity of intestinal gene expression profile signatures reflected by nutritional interventions in piglets.BMC genomics · 2019Pooled it
- The maternal microbiome influence on pregnancy success: breeding comparison of germ-free and conventionalized mice.Gut microbes · 2026Article
- Maternal methionine supplementation in low-protein diets during late gestation and lactation increases performance and alters fecal microbiota of sows and their offspring.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Habitual Ultra-processed Food Intake Is Associated with Gut Dysbiosis and Pro-inflammatory Metabolite Profiles in Korean Patients with IBD.Digestive diseases and sciences · 2026Article
- Maternal methionine supplementation regulates skeletal muscle development through NAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Emergency granulopoiesis and innate immune memory in inflammatory bowel disease.Trends in immunology · 2026Review
- Maternal and infant gut microbiome.iMeta · 2026Review
- Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease: From Dysbiosis to Metagenomic Insights and Therapeutic Perspectives.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Maternal chrononutrition during pregnancy and the composition of intestinal and placental microbiota.BMC pregnancy and childbirth · 2026Article
- Nutritional evaluation of Zanthoxylum bungeanum leaves and their effects on reproductive performance, milk composition, antioxidant status, and gut microbiota in sows.Animal bioscience · 2026Article
- Gut microbiota-derived taurolithocholic acid modulates myofiber-type switching via p38 MAPK/PGC-1α signaling underlying breed differences between Arbor Acres and Taoyuan chickens.Poultry science · 2026Article
- Nanoparticle-based serine replenishment rescues SP1-BNIP3 mitophagy and ameliorates preeclampsia in preclinical models.Cell reports. Medicine · 2026Article
- Rethinking neonatalFrontiers in immunology · 2026Article
- Gut microbiota as a regulator of vaccine efficacy: implications for personalized vaccination.Gut microbes · 2025Review
- Environmental Microbial Cues Alter Embryonic Development and Stress Responses in Vertebrates: Insights From the Zebrafish (Danio rerio) Model.Molecular ecology · 2025Article
- Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate.European journal of immunology · 2025Review
- Review
131 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mucosal surfaces of mammals are densely colonized with microorganisms that are commonly referred to as the commensal microbiota. It is believed that the fetus in utero is sterile and that colonization with microorganisms starts only after birth. Nevertheless, the unborn fetus is exposed to a multitude of metabolites that originate from the commensal microbiota of the mother that reach systemic sites of the maternal body. The intestinal microbiota is strongly personalized and influenced by environmental factors, including nutrition. Members of the maternal microbiota can metabolize dietary components, pharmaceuticals and toxins, which can subsequently be passed to the developing fetus or the breast-feeding neonate. In this Review, we discuss the complex interplay between nutrition, the maternal microbiota and ingested chemicals, and summarize their effects on immunity in the offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.