ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Imaging Microglial Activation in Individuals at Clinical High Risk for Psychosis: an In Vivo PET Study with [
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic Review and Meta-Analysis of Randomized Clinical Trials of Anti-Inflammatory Agents in Early-Stage Psychotic Disorders.Schizophrenia bulletin · 2026Pooled it
- Neuroinflammation in schizophrenia: meta-analysis ofPsychological medicine · 2019Pooled it
- Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data.Biological psychiatry · 2018Pooled it
- A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Tocilizumab, An Interleukin-6 Receptor Antibody, For Residual Symptoms in Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Exploring the Relationship Between Inflammatory Biomarkers and Negative Symptoms Subtypes in Individuals at Ultra-High Risk for Psychosis.Early intervention in psychiatry · 2026Article
- PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation.Molecular neurobiology · 2025Review
- Article
- Neurofilament light-chain (NfL) and 18 kDa translocator protein in early psychosis and its putative high-risk.Brain, behavior, & immunity - health · 2024Article
- Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia.IBRO neuroscience reports · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- In vivo imaging translocator protein (TSPO) in autism spectrum disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Applicability, potential and limitations of TSPO PET imaging as a clinical immunopsychiatry biomarker.European journal of nuclear medicine and molecular imaging · 2021Review
- Immune environment of the brain in schizophrenia and during the psychotic episode: A human post-mortem study.Brain, behavior, and immunity · 2021Review
- Microglia imaging in methamphetamine use disorder: a positron emission tomography study with the 18 kDa translocator protein radioligand [F-18]FEPPA.Addiction biology · 2021Article
- Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System.CNS drugs · 2020Review
- Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline.Translational psychiatry · 2020Article
- Gliosis and Neurodegenerative Diseases: The Role of PET and MR Imaging.Frontiers in cellular neuroscience · 2020Review
- Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis.Frontiers in psychiatry · 2020Article
- Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion.Frontiers in psychiatry · 2020Review
- Personality traits in psychosis and psychosis risk linked to TSPO expression: a neuroimmune marker.Personality neuroscience · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Several lines of evidence implicate microglial activation and abnormal immune response in the etiology of psychosis. Previous positron emission tomography (PET) neuroimaging studies of the translocator protein 18 kDa, TSPO, were limited by low affinity of the first-generation radioligand, low-resolution scanners, and small sample sizes. Moreover, there is a dearth of literature on microglial activation in individuals at clinical high risk (CHR) for psychosis. We used a novel second-generation TSPO radioligand, [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.