ArticleNature genetics2017
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 12 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Identification of therapeutic targets for insomnia through genetic and plasma proteomic approaches.Medicine · 2025Pooled it
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude.Clinical epigenetics · 2023Pooled it
- Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Pooled it
- Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.Nature genetics · 2022Pooled it
- Pooled it
- Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.Psychological medicine · 2021Pooled it
- Pooled it
- Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis.JAMA psychiatry · 2020Pooled it
- Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.Nature genetics · 2019Pooled it
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.Nature genetics · 2019Pooled it
- A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2018Pooled it
- The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Trial
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- Phenotype Refinement Influences GWAS-Implicated Variant Effect Sizes for Insomnia.Journal of sleep research · 2026Article
- Insomnia and women: exploring vulnerability, impact, and intervention.Sleep & breathing = Schlaf & Atmung · 2026Review
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Hyperarousal transdiagnostically dissected: different dimensions characterize mood, anxiety, insomnia, posttraumatic stress and attention deficit hyperactivity disorders.EClinicalMedicine · 2026Article
- Heart rate phase is an indicator of chronotype-relevant circadian shifts associated with human disease: an All of Us Research Program analysis.The Journal of physiology · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint analysis with an independent sample (n = 7,565). Our top association (MEIS1, P < 5 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.