Evidence map›Paper›PMID 28604730›Full record

SynthesisNature genetics2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

James D McKay, Rayjean J Hung, Younghun Han, Xuchen Zong, Robert Carreras-Torres, David C Christiani, Neil E Caporaso, Mattias Johansson, Xiangjun Xiao, Yafang Li and 131 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 481 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
481citing papers in PubMed, 16 pooled it
41.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

481 citing papers in PubMed, 16 syntheses or guidelines pooled it, 774 citations in OpenAlex.

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421 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

141 authors at 20 institutions in 24 countries.

James D McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Younghun HanBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Xuchen ZongLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Robert Carreras-TorresInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Mattias JohanssonInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Xiangjun XiaoBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Yafang LiBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Jinyoung ByunBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID http://orcid.org/0000-0001-8579-1435
Alison DunningCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Karen A PooleyCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
David C QianBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Xuemei JiBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Geoffrey LiuLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Maria N TimofeevaInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID http://orcid.org/0000-0002-2503-4253
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Xifeng WuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Demetrios AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
William S BushDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Adonina TardonUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.
Gad RennertClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
M Dawn TeareSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
John K FieldInstitute of Translational Medicine, University of Liverpool, Liverpool, UK.
Lambertus A KiemeneyDepartments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, the Netherlands.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA.
Aage HaugenNational Institute of Occupational Health, Oslo, Norway.
Stephen LamBritish Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Angeline S AndrewDepartment of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire, USA.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jian-Min YuanUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Pier Alberto BertazziDepartment of Preventive Medicine, IRCCS Foundation Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0003-3475-2449
Angela C PesatoriDepartment of Clinical Sciences and Community Health-DISCCO, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-0261-3252
Yuanqing YeDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nancy DiaoDepartment of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.
Li SuDepartment of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.
Ruyang ZhangDepartment of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/ Harvard Medical School, Boston, Massachusetts, USA.
Yonathan BrhaneLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Natasha LeighlUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Jakob S JohansenDepartment of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Anders MellemgaardDepartment of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Walid SalibaClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Ana Fernandez-SomoanoUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.
Guillermo Fernandez-TardonUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.
Henricus F M van der HeijdenDepartments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0003-3596-518X
Jin Hee KimDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.
Juncheng DaiDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Zhibin HuDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Michael P A DaviesInstitute of Translational Medicine, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-7609-4977
Michael W MarcusInstitute of Translational Medicine, University of Liverpool, Liverpool, UK.
Hans BrunnströmDepartment of Pathology, Lund University, Lund, Sweden.
Jonas ManjerFaculty of Medicine, Lund University, Lund, Sweden.
Olle MelanderFaculty of Medicine, Lund University, Lund, Sweden.
David C MullerSchool of Public Health, St Mary's Campus, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2350-0417
Kim OvervadSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Rosario TuminoMolecular and Nutritional Epidemiology Unit, CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence, Italy.
Jennifer A DohertyDepartment of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire, USA.
Matt P BarnettProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Chu ChenProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Gary E GoodmanSwedish Medical Group, Seattle, Washington, USA.
Angela CoxDepartment of Oncology, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0002-5138-1099
Fiona TaylorDepartment of Oncology, University of Sheffield, Sheffield, UK.
Penella WollDepartment of Oncology, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0002-1118-0831
Irene BrüskeInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
H-Erich WichmannInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Judith ManzResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Thomas R MuleyThoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
Angela RischResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8026-5505
Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0003-4289-2097
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Frances A ShepherdUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Ming-Sound TsaoUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Susanne M ArnoldMarkey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.
Eric B HauraDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Ciprian BolcaInstitute of Pneumology 'Marius Nasta', Bucharest, Romania.
Ivana Holcatova2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Vladimir JanoutFaculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Milica KonticClinical Center of Serbia, Belgrade, Serbia.
Jolanta LissowskaM. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw, Poland.
Anush MukeriaDepartment of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow, Russian Federation.
Simona OgnjanovicInternational Organization for Cancer Prevention and Research, Belgrade, Serbia.
Tadeusz M OrlowskiDepartment of Surgery, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Ghislaine SceloInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Beata SwiatkowskaNofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland.
David ZaridzeDepartment of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre, Moscow, Russian Federation.
Per BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Vidar SkaugNational Institute of Occupational Health, Oslo, Norway.
Shanbeh ZienolddinyNational Institute of Occupational Health, Oslo, Norway.
Eric J DuellUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Lesley M ButlerUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Woon-Puay KohDuke-National University of Singapore Medical School, Singapore.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Richard S HoulstonThe Institute of Cancer Research, London, UK.
John McLaughlinPublic Health Ontario, Toronto, Ontario, Canada.
Victoria L StevensAmerican Cancer Society, Atlanta, Georgia, USA.
Philippe JoubertInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Maxime LamontagneInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
David C NickleMerck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.
Ma'en ObeidatUniversity of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-5443-2752
Wim TimensUniversity of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-4146-6363
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Lei SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Linda KachuriLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
María Soler ArtigasGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Martin D TobinGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-3596-7874
Louise V WainGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-4951-1867
SpiroMeta Consortium
Thorunn RafnardeCODE Genetics, Amgen, Inc., Reykjavik, Iceland.
Thorgeir E ThorgeirssondeCODE Genetics, Amgen, Inc., Reykjavik, Iceland.
Gunnar W ReginssondeCODE Genetics, Amgen, Inc., Reykjavik, Iceland.
Kari StefanssondeCODE Genetics, Amgen, Inc., Reykjavik, Iceland.
Dana B HancockBehavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina, USA.ORCID http://orcid.org/0000-0003-2240-3604
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Margaret R SpitzDuncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Nathan C GaddisResearch Computing Division, RTI International, Research Triangle Park, North Carolina, USA.
Sharon M LutzDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Fangyi GuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Eric O JohnsonFellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, North Carolina, USA.
Ahsan KamalBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Claudio PikielnyBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Dakai ZhuBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Sara LindströemDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Xia JiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Rachel F TyndaleDepartments of Pharmacology and Toxicology &Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jonathan BeesleyCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Yohan BosséInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.ORCID http://orcid.org/0000-0002-3067-3711
Stephen ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Paul BrennanInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Christopher I AmosBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Dartmouth College · USCentre international de recherche sur le cancer · FRNational Institutes of Health · USHarvard University · USUniversity of Toronto · CAdeCODE Genetics (Iceland) · ISUniversity of Sheffield · GBHelmholtz Zentrum München · DEInstitut universitaire de cardiologie et de pneumologie de Québec · CALund University · SENanjing Medical University · CNNational Institute of Occupational Health · NORTI International · USUniversidad de Oviedo · ESUniversity Health Network · CAUniversity of Leicester · GBUniversity of Liverpool · GBCarmel Medical Center · ILFred Hutch Cancer Center · USGentofte Hospital · DK

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5M
SPORE in Lung CancerP50CA119997 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GABRILOVICH, DMITRY I · 2008 to 2012
$11.0M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Transdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9M
INFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8M
Telomeres and lung cancer incidence and survivalR01CA151989 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DOHERTY, JENNIFER A. · 2011 to 2014
$2.4M
Utilizing Interaction to Identify Novel Genetic Factors for Nicotine DependenceR01DA035825 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI HANCOCK, DANA B · 2013 to 2015
$1.5M
Unraveling Genetic Determinants of Lung Cancer Risk in African AmericansK07CA172294 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALDRICH, MELINDA · 2013 to 2017
$801k
Cancer Research UK 20622Medical Research Council G0902313Medical Research Council MR/N011317/1NCI NIH HHS K07 CA172294NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA119997NCI NIH HHS R01 CA151989NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148127NCI NIH HHS UM1 CA167462NIDA NIH HHS R01 DA035825Wellcome Trust 202849/Z/16/ZWorld Health Organization 001
6 · The paper itself

Abstract

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

Indexed as

Genome-Wide Association StudyAdenocarcinomaAdenocarcinoma of LungAdultAgedChromosome MappingFamily HealthFemaleGenetic Predisposition to DiseaseGenotypeHumansLung NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait Loci

Identifiers

PMID28604730
PMCPMC5510465
OpenAlexW2612427157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.