ArticleNature methods2017
Visualizing adenosine-to-inosine RNA editing in single mammalian cells.
Article in Nature methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Spatial transcriptomics reveals laminar and cell-type-specific A-to-I RNA editing signatures in the macaque cortex.Nature communications · 2026Article
- Multifaceted role of inosine in complex diseases and human health.Nutrition reviews · 2025Review
- EndoVIA for quantifying A-to-I editing and mapping the subcellular localization of edited transcripts.Methods in enzymology · 2025Article
- Spatial omics advances for in situ RNA biology.Molecular cell · 2024Review
- Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V Immunostaining Assay (EndoVIA).ACS central science · 2024Article
- In situ visualization of m6A sites in cellular mRNAs.Nucleic acids research · 2023Article
- Technical Advances and Applications of Spatial Transcriptomics.GEN biotechnology · 2023Article
- Semi-quantitative detection of pseudouridine modifications and type I/II hypermodifications in human mRNAs using direct long-read sequencing.Nature communications · 2023Article
- Achieving single nucleotide sensitivity in direct hybridization genome imaging.Nature communications · 2022Article
- Illuminating RNA biology through imaging.Nature cell biology · 2022Review
- Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches.Nature communications · 2022Article
- p53 mediates target gene association with nuclear speckles for amplified RNA expression.Molecular cell · 2021Article
- Review
- Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.Nucleic acids research · 2020Article
- Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells.Cell stem cell · 2020Review
- Click-encoded rolling FISH for visualizing single-cell RNA polyadenylation and structures.Nucleic acids research · 2019Article
- Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting.PLoS genetics · 2019Article
- Imaging the Life and Death of mRNAs in Single Cells.Cold Spring Harbor perspectives in biology · 2018Review
- ClampFISH detects individual nucleic acid molecules using click chemistry-based amplification.Nature biotechnology · 2018Article
- Splicing heterogeneity: separating signal from noise.Genome biology · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Conversion of adenosine to inosine is a frequent type of RNA editing, but important details about the biology of this conversion remain unknown because of a lack of imaging tools. We developed inoFISH to directly visualize and quantify adenosine-to-inosine-edited transcripts in situ. We found that editing of the GRIA2, EIF2AK2, and NUP43 transcripts is uncorrelated with nuclear localization and paraspeckle association. Further, NUP43 exhibits constant editing levels between single cells, while GRIA2 editing levels vary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.