ArticleNature immunology2017
The transcription factor Runx3 guards cytotoxic CD8
Abstract read
In one paragraph
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed.
- Temporal and transcriptional programming of effector memory B cells shapes vaccine platform-dependent humoral immunity.iScience · 2026Article
- RUNX3: a regulator of macrophage apoptosis with positive prognostic impact in sepsis.Genes & genomics · 2026Article
- ATF7ip Inhibits the Tumor Immune Response by Promoting Terminal CD8+ T-cell Exhaustion.Cancer immunology research · 2026Article
- CD8MedComm · 2026Review
- Article
- Arid3b suppresses CD8 + T cell infiltration and function in microsatellite-stable colorectal cancer via Runx3.Nature communications · 2026Article
- Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity.The Journal of experimental medicine · 2026Article
- Immunoprofiling, sex- and age-related determinants of treatment response in paediatric, adolescent and young adult Hodgkin lymphoma.British journal of haematology · 2026Article
- The CD8 immgenT framework as a universal reference of mouse CD8αβ T cell differentiation states.bioRxiv : the preprint server for biology · 2026Article
- An early burst of cytokine production before the first cell division influences CD8 T cell differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Single-Cell Targeted Transcriptomics Reveals Subset-Specific Immune Signatures Differentiating Asymptomatic and Cardiac Patients With Chronic Chagas Disease.The Journal of infectious diseases · 2025Article
- The transcription factor BATF pioneers the differentiation program of effector CD8Cell reports · 2025Article
- HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection.The Journal of experimental medicine · 2025Article
- Chromatin landscape alteration uncovers multiple transcriptional circuits during memory CD8+ T-cell differentiation.Protein & cell · 2025Article
- Gfi1 controls the formation of effector-like CD8Nature communications · 2025Article
- Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.JCI insight · 2025Article
- Targeting PD-1 and CD85j can restore intratumoral CD4Journal for immunotherapy of cancer · 2025Article
- Regulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease.Cell communication and signaling : CCS · 2024Review
- Epigenetics behind CD8Genes and immunity · 2024Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Qiang ShanDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Zhouhao ZengDepartment of Physics, The George Washington University, Washington DC, USA.
Shaojun XingDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Fengyin LiDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Stacey M HartwigDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Jodi A GullicksrudDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Samarchith P KurupDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Natalija Van Braeckel-BudimirDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Yao SuState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Science, Beijing, P.R. China.
Matthew D MartinDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Steven M VargaDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Ichiro TaniuchiRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
John T HartyDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Weiqun PengDepartment of Physics, The George Washington University, Washington DC, USA.
Vladimir P BadovinacDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Hai-Hui XueDepartment of Microbiology, University of Iowa, Iowa City, Iowa, USA.
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7MTcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4MRegulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7MTcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6MMemory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4MT resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4MImpairment and recovery of CD8 T cell responses after sepsisR01GM113961 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2015 to 2018
$1.2MFlow Cytometry Cell SorterS10OD016199 · OD · UNIVERSITY OF IOWA · PI BALLAS, ZUHAIR K. · 2015 to 2015
$443kEpigenomic landscape in naive, effector, and memory CD8 T cellsR21AI115149 · NIAID · UNIVERSITY OF IOWA · PI TAN, KAI, XUE, HAI-HUI · 2015 to 2016
$417kCharacterization of Regulated Intron Retention in T Cell ActivationR21AI113806 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI HAWLEY, ROBERT G., PENG, WEIQUN · 2014 to 2015
$417kMolecular mechanisms controlling differentiation of memory CD8 T cellsR21AI119160 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, XUE, HAI-HUI · 2015 to 2016
$414kBLRD VA I01 BX002903NCI NIH HHS P30 CA086862NIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080NIAID NIH HHS R21 AI042767NIAID NIH HHS R21 AI113806NIAID NIH HHS R21 AI115149NIAID NIH HHS R21 AI119160NIAID NIH HHS R37 AI042767NIAID NIH HHS T32 AI007260NIGMS NIH HHS R01 GM113961NIH HHS S10 OD016199
Abstract
Activated CD8
Indexed as
AnimalsCell LineageCore Binding Factor Alpha 3 SubunitEnzyme-Linked Immunosorbent AssayEpigenesis, GeneticGene Expression RegulationHepatocyte Nuclear Factor 1-alphaImmunohistochemistryLymphopoiesisMiceProto-Oncogene Proteins c-bcl-6Receptors, CXCR5Reverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNAT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerBcl6 protein, mouseCore Binding Factor Alpha 3 SubunitCXCR5 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseProto-Oncogene Proteins c-bcl-6Receptors, CXCR5Runx3 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.