ArticleNature communications2017
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- UBE2C at the crossroads of cell cycle regulation and DNA damage response in cancer.Cell biology and toxicology · 2026Review
- CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice.Oncogene · 2024Article
- PTEN-mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells.Molecular oncology · 2024Article
- The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment.Frontiers in oncology · 2023Article
- Article
- Multifaceted regulation and functions of 53BP1 in NHEJ‑mediated DSB repair (Review).International journal of molecular medicine · 2022Review
- Article
- Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease.Molecular neurobiology · 2022Article
- CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells.PloS one · 2022Article
- Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis.Frontiers in cell and developmental biology · 2022Review
- Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair.Frontiers in cell and developmental biology · 2022Review
- APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.Seminars in cancer biology · 2020Review
- Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy.Cancer science · 2020Article
- Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response.Biochemical Society transactions · 2019Review
- The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.Scientific reports · 2019Article
- Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Applications of Genome Editing Technology in Animal Disease Modeling and Gene Therapy.Computational and structural biotechnology journal · 2019Review
- Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.The EMBO journal · 2018Article
- The anaphase promoting complex promotes NHEJ repair through stabilizing Ku80 at DNA damage sites.Cell cycle (Georgetown, Tex.) · 2018Article
- Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cellsInternational journal of biological sciences · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 7 institutions in 4 countries.
Kyungsoo HaNational Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China.
Chengxian MaDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China.
Han LinDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-8569-7972
Lichun TangNational Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China.
Zhusheng LianDepartment of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China.
Fang ZhaoNational Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China.
Ju-Mei LiDepartment of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA.
Bei ZhenNational Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China.
Huadong PeiNational Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China.
Suxia HanDepartment of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China.
Marcos MalumbresSpanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain.ORCID 0000-0002-0829-6315
Jianping JinDepartment of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA.
Huan ChenNational Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China.
Yongxiang ZhaoNational Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China.
Qing ZhuDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China.
Pumin ZhangNational Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China.
Beijing Proteome Research Center · CNBaylor College of Medicine · USFirst Affiliated Hospital of Xi'an Jiaotong University · CNGuangxi Medical University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNThe University of Texas Health Science Center at Houston · USSpanish National Cancer Research Centre · ES
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3MVirology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7MTRANSGENIC MOUSE MODELS TO STUDY OVARIAN FUNCTIONU54HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI RICHARDS, JOANNE STEWART · 1998 to 2013
$19.9MSpindle Assembly Checkpoint, Chromosome Stability, and CancerR01CA122623 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2008 to 2016
$2.8MThe Function of Cdc14B in DNA Damage Repair and TumorigenesisR01CA116097 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2006 to 2015
$2.6MGROWTH AND DIFFERENTIATION IN EUKARYOTEST32HD007495 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KINTNER, CHRISTOPHER ROBERT · 1995 to 2009
$1.6MPost-ubiquitinational Regulation of I-kappa-B-alpha Proteolysis under StimuliR01GM102529 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JIN, JIANPING · 2012 to 2016
$1.4MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kTRANSGENIC ANIMAL--COREP30HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GLASSER, STANLEY R · 1985 to 1997
–NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA116097NCI NIH HHS R01 CA122623NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NICHD NIH HHS P30 HD007495NICHD NIH HHS T32 HD007495NICHD NIH HHS U54 HD007495NIDDK NIH HHS P30 DK056338NIGMS NIH HHS R01 GM102529
Abstract
Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is the repair choice made in S/G2 cells? Here we provide evidence demonstrating that APC
Indexed as
DNA DamageAnaphase-Promoting Complex-CyclosomeAnimalsCell LineDNA Breaks, Double-StrandedDNA RepairGenomic InstabilityHEK293 CellsHeLa CellsHumansMiceModels, GeneticSignal TransductionUbiquitinAnaphase-Promoting Complex-CyclosomeUbiquitin
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.