Evidence map›Paper›PMID 28604244›Full record

ArticleHuman vaccines & immunotherapeutics2017

N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride: An immune-enhancing adjuvant for hepatitis E virus recombinant polypeptide vaccine in mice.

Wei Tao, Hai-Qun Zheng, Ting Fu, Zhuo-Jing He, Yan Hong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei Taoa Institute of Bioengineering, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P. R. China.
Hai-Qun Zhenga Institute of Bioengineering, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P. R. China.
Ting Fua Institute of Bioengineering, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P. R. China.
Zhuo-Jing Hea Institute of Bioengineering, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P. R. China.
Yan Honga Institute of Bioengineering, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P. R. China.
Zhejiang Academy of Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adjuvants are essential for enhancing vaccine potency by improving the humoral and/or cell-mediated immune response to vaccine antigens. This study was performed to evaluate the immuno-enhancing characteristic of N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC), the cationically modified chitosan, as an adjuvant for hepatitis E virus (HEV) recombinant polypeptide vaccine. Animal experiments showed that HTCC provides adjuvant activity when co-administered with HEV recombinant polypeptide vaccine by intramuscularly route. Vaccination using HTCC as an adjuvant was associated with increases of the serum HEV-specific IgG antibodies, splenocytes proliferation and the growths of CD4

Indexed as

Adjuvants, ImmunologicAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChitosanHepatitis AntibodiesHepatitis EHepatitis E virusImmunity, CellularImmunity, HumoralImmunogenicity, VaccineImmunoglobulin GMiceMice, Inbred BALB CPeptidesQuaternary Ammonium CompoundsAdjuvants, ImmunologicChitosanHepatitis AntibodiesImmunoglobulin GN-(2-hydroxypropyl)-3-trimethylammonium chitosanPeptidesQuaternary Ammonium CompoundsVaccines, SyntheticViral Hepatitis Vaccinesadjuvantcell-mediated immunityhepatitis E virushumoral immunityN-(2-hydroxy) propyl-3-trimethylammonium chitosan chloridevaccine

Identifiers

PMID28604244
PMCPMC5557240
OpenAlexW2626500729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.