ArticleASN neuro
Heterogeneity of D-Serine Distribution in the Human Central Nervous System.
Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.APL bioengineering · 2026Review
- Impact of D-Amino Acids in Schizophrenia.Biomolecules · 2025Review
- Mammalian Tolerance to Amino Acid Heterochirality.Chembiochem : a European journal of chemical biology · 2025Review
- Urinary D-asparagine level is decreased by the presence of glioblastoma.Acta neuropathologica communications · 2024Article
- Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration.Neurobiology of disease · 2023Article
- Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.Scientific reports · 2022Article
- D-Amino Acids as a Biomarker in Schizophrenia.Diseases (Basel, Switzerland) · 2022Review
- Circulating metabolites associated with tumor hypoxia and early response to treatment in bevacizumab-refractory glioblastoma after combined bevacizumab and evofosfamide.Frontiers in oncology · 2022Article
- Article
- Electro-Acupuncture Regulates Metabolic Disorders of the Liver and Kidney in Premature Ovarian Failure Mice.Frontiers in endocrinology · 2022Article
- Simultaneous Measurement of Amino Acid Enantiomers in Aged Mouse Brain Samples by LC/MS/MS Combined with Derivatization UsingMetabolites · 2021Article
- D-Amino acids and kidney diseases.Clinical and experimental nephrology · 2020Review
- Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum.Clinical epigenetics · 2019Article
- d-amino Acids in Health and Disease: A Focus on Cancer.Nutrients · 2019Review
- Investigating brain d-serine: Advocacy for good practices.Acta physiologica (Oxford, England) · 2019Review
- Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.Frontiers in molecular biosciences · 2019Review
- Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats.Behavioral sciences (Basel, Switzerland) · 2018Article
- DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.Scientific reports · 2018Article
- Emerging Role of D-Amino Acid Metabolism in the Innate Defense.Frontiers in microbiology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
D-serine is an endogenous ligand for N-methyl-D-aspartate glutamate receptors. Accumulating evidence including genetic associations of D-serine metabolism with neurological or psychiatric diseases suggest that D-serine is crucial in human neurophysiology. However, distribution and regulation of D-serine in humans are not well understood. Here, we found that D-serine is heterogeneously distributed in the human central nervous system (CNS). The cerebrum contains the highest level of D-serine among the areas in the CNS. There is heterogeneity in its distribution in the cerebrum and even within the cerebral neocortex. The neocortical heterogeneity is associated with Brodmann or functional areas but is unrelated to basic patterns of cortical layer structure or regional expressional variation of metabolic enzymes for D-serine. Such D-serine distribution may reflect functional diversity of glutamatergic neurons in the human CNS, which may serve as a basis for clinical and pharmacological studies on D-serine modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.