ArticleHuman brain mapping2017
Dynamic brain connectivity is a better predictor of PTSD than static connectivity.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Classification of neurodegenerative diseases using brain effective connectivity and machine learning techniques: a systematic review.Frontiers in neurology · 2025Pooled it
- Effects of acute Δ9-tetrahydrocannabinol on next-day extinction recall is mediated by post-extinction resting-state brain dynamics.Neuropharmacology · 2018Trial
- Transcranial direct current stimulation and lesions hierarchically reorganize brain network dynamics with biological annotations.Fundamental research · 2026Article
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Dynamic and Static Resting-State Functional Connectivity of Canonical Networks in Military and Civilian Populations With Posttraumatic Stress Disorder and/or Mild Traumatic Brain Injury.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Disrupted self-referential processing and empathy-based interventions in mental disorders: neural mechanisms, cognitive biases, and therapeutic integration.Frontiers in psychiatry · 2026Review
- Predicting PTSD development with early post-trauma assessments: a proof-of-concept for a concise tree-based classification method.European journal of psychotraumatology · 2025Article
- Lag-structure in fMRI across Three Psychiatric Groups: State-dependency and Clinical-behavioral Correlates.Brain topography · 2025Article
- Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study.Human brain mapping · 2025Article
- Static and Dynamic Cross-Network Functional Connectivity Shows Elevated Entropy in Schizophrenia Patients.Human brain mapping · 2025Article
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- Exploring the impact of biological sex on intrinsic connectivity networks in PTSD: A data-driven approach.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- RCE-IFE: recursive cluster elimination with intra-cluster feature elimination.PeerJ. Computer science · 2025Article
- Altered brain state dynamics between preterm and term-born infants.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Topology Assisted Clustering of Temporal fMRI Brain Networks With Use-Case in Mitigating Non-Neural Multi-Site Variability.IEEE access : practical innovations, open solutions · 2025Article
- Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease.Human brain mapping · 2024Article
- Static and Dynamic Cross-Network Functional Connectivity Shows Elevated Entropy in Schizophrenia Patients.bioRxiv : the preprint server for biology · 2024Article
- Applications of artificial intelligence-machine learning for detection of stress: a critical overview.Molecular psychiatry · 2024Review
- The application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis.NPJ digital medicine · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using resting-state functional magnetic resonance imaging, we test the hypothesis that subjects with post-traumatic stress disorder (PTSD) are characterized by reduced temporal variability of brain connectivity compared to matched healthy controls. Specifically, we test whether PTSD is characterized by elevated static connectivity, coupled with decreased temporal variability of those connections, with the latter providing greater sensitivity toward the pathology than the former. Static functional connectivity (FC; nondirectional zero-lag correlation) and static effective connectivity (EC; directional time-lagged relationships) were obtained over the entire brain using conventional models. Dynamic FC and dynamic EC were estimated by letting the conventional models to vary as a function of time. Statistical separation and discriminability of these metrics between the groups and their ability to accurately predict the diagnostic label of a novel subject were ascertained using separate support vector machine classifiers. Our findings support our hypothesis that PTSD subjects have stronger static connectivity, but reduced temporal variability of connectivity. Further, machine learning classification accuracy obtained with dynamic FC and dynamic EC was significantly higher than that obtained with static FC and static EC, respectively. Furthermore, results also indicate that the ease with which brain regions engage or disengage with other regions may be more sensitive to underlying pathology than the strength with which they are engaged. Future studies must examine whether this is true only in the case of PTSD or is a general organizing principle in the human brain. Hum Brain Mapp 38:4479-4496, 2017. © 2017 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.