Trial reportHuman brain mapping2017
Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism.
Trial report in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Neural correlates of acute task-related stress in humans: a systematic review and coordinate-based ALE meta-analysis.Brain imaging and behavior · 2026Pooled it
- Common and Distinct Neural Mechanisms Underlying Risk Seeking and Risk Aversion: Evidence From the Neuroimaging Meta-Analysis.Human brain mapping · 2025Pooled it
- Pooled it
- Risk-taking in the human brain: An activation likelihood estimation meta-analysis of the balloon analog risk task (BART).Human brain mapping · 2022Pooled it
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Prefrontal tDCS modulates risk-taking in male violent offenders.Scientific reports · 2024Trial
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Association of the MAOA-uVNTR polymorphism with psychopathic traits may change from childhood to adolescence.European archives of psychiatry and clinical neuroscience · 2022Article
- Risky decision-making strategies mediate the relationship between amygdala activity and real-world financial savings among individuals from lower income households: A pilot study.Behavioural brain research · 2022Article
- Testosterone administration does not alter the brain activity supporting cognitive and affective empathy.Comprehensive psychoneuroendocrinology · 2022Article
- A Bayesian Modeling Approach to Examine the Role of Testosterone Administration on the Endowment Effect and Risk-Taking.Frontiers in neuroscience · 2022Article
- A Combined Administration of Testosterone and Arginine Vasopressin Affects Aggressive Behavior in Males.Brain sciences · 2021Article
- Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.NeuroImage · 2020Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Effects of exogenous testosterone application on network connectivity within emotion regulation systems.Scientific reports · 2020Article
- Single-Dose of Testosterone and theFrontiers in behavioral neuroscience · 2020Article
- MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer's Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance.Molecular neurobiology · 2019Article
- Tobacco and cannabis use in college students are predicted by sex-dimorphic interactions between MAOA genotype and child abuse.CNS neuroscience & therapeutics · 2019Article
- Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone, a male sex hormone, has been suggested to partly explain mixed findings in males and females when investigating behavioral tendencies associated with the MAOA polymorphism. Prior studies indicated that the MAOA polymorphism represents a vulnerability factor for financial risk-taking and harm avoidance and that testosterone increases human risk-taking. We therefore assumed an interactive influence of the MAOA polymorphism and testosterone application on decision making and corresponding neural correlates in a risk and reward context. Stratified for the MAOA polymorphism (S =short, L =long), 103 healthy males were assigned to a placebo or testosterone group (double blind, randomized) receiving a topical gel containing 50 mg testosterone. During a functional MRI scan, the participants performed a sequential decision making task. Our results indicate that testosterone and the MAOA polymorphism jointly influence sequential decision making. The MAOA-S variant was associated with less automatic harm avoidance as reflected in response times on safe decisions. Moreover, after testosterone administration, MAOA-S carriers were more risk-taking. Overall activity in the anterior cingulate cortex, anterior insula and inferior frontal gyrus increased with growing risk for losses. In the anterior insula, testosterone administration mitigated this effect solely in MAOA-S carriers. This might be a reflection of an improved coping during risk-reward conflicts subsequently modulating risky decision making. While the molecular basis is not well defined so far, our results support the assumption of testosterone as a modulatory factor for previously reported sex differences of behavioral associations with the MAOA-S variant. Hum Brain Mapp 38:4574-4593, 2017. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.