Evidence map›Paper›PMID 28603768›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017

Consensus guidelines for lumbar puncture in patients with neurological diseases.

Sebastiaan Engelborghs, Ellis Niemantsverdriet, Hanne Struyfs, Kaj Blennow, Raf Brouns, Manuel Comabella, Irena Dujmovic, Wiesje van der Flier, Lutz Frölich, Daniela Galimberti and 28 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 186 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 9 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03507257 active not recruitingnot on this mapstarted 2018, after this paper: background citation

Longitudinal Early-onset Alzheimer's Disease Study Protocol

TypeobservationalSponsorIndiana UniversityRan2018 to 2027Enrolled850ConditionsEarly Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive ImpairmentArmsFlortaucipir, Florbetaben, Fluorodeoxyglucose
NCT04328974 completednot on this mapstarted 2021, after this paper: background citation

The Effect of Lumbar Cerebrospinal Fluid Drainage on the Neurologic Outcome Improvement in Out of Hospital Cardiac Arrest Patients Underwent Targeted Temperature Management

Typeobservational_patient_registrySponsorChungnam National University HospitalRan2021 to 2024Enrolled40ConditionsHeart Arrest, Out-Of-Hospital, Brain SwellingArmslumbar CSF drainage
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 9 syntheses or guidelines pooled it, 343 citations in OpenAlex.

  1. Beyond papilledema: optic disc clues reveal coexisting Chiari I malformation and osteopetrosis-a case report and systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  2. Guideline
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  7. Systematic Review of Brain-Eating Amoeba: A Decade Update.International journal of environmental research and public health · 2023
    Pooled it
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  9. Blood DNA methylation as a potential biomarker of dementia: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018
    Pooled it
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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 16 countries.

Sebastiaan EngelborghsReference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Ellis NiemantsverdrietReference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Hanne StruyfsReference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Kaj BlennowClinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Raf BrounsDepartment of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Manuel ComabellaServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Receca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Irena DujmovicClinic of Neurology, Clinical Centre of Serbia, Department of Neurology, Faculty of Medicine, University of Belgrade School of Medicine, Belgrade, Serbia.
Wiesje van der FlierAlzheimer center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Lutz FrölichDepartment of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
Daniela GalimbertiNeurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Sharmilee GnanapavanDepartment of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, United Kingdom.
Bernhard HemmerDepartment of Neurology, Technische Universität München, Munich, Germany.
Erik HoffDepartment of Neurology, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands.
Jakub HortMemory Disorders Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
Ellen IacobaeusDepartment of Clinical Neuroscience, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Martin IngelssonDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Frank Jan de JongDepartment of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Michael JonssonMemory Clinic, Department of Neuropsychiatry, Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Michael KhalilDepartment of Neurology, Medical University Graz, Graz, Austria.
Jens KuhleDepartment of Neurology, University Hospital Basel, Basel, Switzerland.
Alberto LleóMemory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Alexandre de MendonçaLaboratory of Neurosciences, Department of Molecular Medicine and Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
José Luis MolinuevoAlzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clinic i Universitari, IDIBAPS, Barcelona, Spain.
Guy NagelsDepartment of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Claire PaquetResearch Memory Center Lariboisière Hospital University Paris Diderot INSERMU942, Paris, France.
Lucilla ParnettiSection of Neurology, Centre for Memory Disturbances, Department of Medicine, University of Perugia, Perugia, Italy.
Gerwin RoksDepartment of Neurology, St Elisabeth Ziekenhuis, Tilburg, The Netherlands.
Pedro Rosa-NetoDepartments of Neurology & Neurosurgery and Psychiatry, McGill Centre for Studies in Aging, Douglas Hospital Research Center, McGill University, Montreal, Canada.
Philip ScheltensAlzheimer center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Constance SkårsgardDepartment of Geriatrics, Kalmar County Hospital, Kalmar, Sweden.
Erik StomrudClinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
Hayrettin TumaniCSF Laboratory and Multiple Sclerosis Outpatient Unit, Department of Neurology, University of Ulm, Ulm, Germany.
Pieter Jelle VisserNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Anders WallinMemory Clinic, Department of Neuropsychiatry, Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Bengt WinbladKarolinska Institutet, Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division for Neurogeriatrics, Huddinge, Sweden.
Henrik ZetterbergClinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Flora DuitsAlzheimer center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Charlotte E TeunissenNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam Neuroscience · NLUniversity of Gothenburg · SEKarolinska Institutet · SEUniversity of Antwerp · BEAtrium Medisch Centrum Parkstad · NLCharles University · CZDouglas Mental Health University Institute · CAErasmus MC · NLHeidelberg University · DEHospital Clínic de Barcelona · ESHospital de Sant Pau · ESInserm · FRLandstinget i Kalmar län · SELund University · SEMaastricht University · NLMedical University of Graz · ATMunich Cluster for Systems Neurology · DEQueen Mary University of London · GBSt. Elisabeth Hospital · CWUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain.

methodsWe provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III).

resultsOur consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. DISCUSSION: When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

Indexed as

Back painCerebrospinal fluidConsensus guidelinesEvidence-based guidelinesHeadacheLumbar puncturePost-LP complications

Identifiers

PMID28603768
PMCPMC5454085
OpenAlexW2615461910

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.