Evidence map›Paper›PMID 28603712›Full record

ReviewFrontiers in cell and developmental biology2017

Growth Rate as a Direct Regulator of the Start Network to Set Cell Size.

Martí Aldea, Kirsten Jenkins, Attila Csikász-Nagy

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Eukaryotic RNA Polymerases: The Many Ways to Transcribe a Gene.Frontiers in molecular biosciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Martí AldeaMolecular Biology Institute of Barcelona, Consejo Superior de Investigaciones CientíficasBarcelona, Spain.
Kirsten JenkinsRandall Division of Cell and Molecular Biophysics and Institute of Mathematical and Molecular Biomedicine, King's College LondonLondon, United Kingdom.
Attila Csikász-NagyRandall Division of Cell and Molecular Biophysics and Institute of Mathematical and Molecular Biomedicine, King's College LondonLondon, United Kingdom.
Consejo Superior de Investigaciones Científicas · ESKing's College London · GBPázmány Péter Catholic University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their size as a function of growth rate. This universal feature suggests that growth (mass) and proliferation (cell number) rates are subject to general coordinating mechanisms. However, the underlying molecular connections are still a matter of debate. Here we review the current ideas on growth and cell size control, and focus on the possible mechanisms that could link the biosynthetic machinery to the Start network in budding yeast. In particular, we discuss the role of molecular chaperones in a competition framework to explain cell size control by growth at the individual cell level.

Indexed as

budding yeastcell cyclecell sizemathematical modelsize control

Identifiers

PMID28603712
PMCPMC5445111
OpenAlexW2617673033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.