Evidence map›Paper›PMID 28603691›Full record

ArticleJournal of clinical & translational endocrinology2016

Use of cystatin C to inform metformin eligibility among adult veterans with diabetes.

Delphine S Tuot, Rebecca Scherzer, Howard Leong, Adriana M Hung, Carl Grunfeld, Michael G Shlipak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & translational endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Delphine S TuotDivision of Nephrology, University of California, San Francisco, CA, USA.
Rebecca ScherzerDepartment of Medicine, University of California, San Francisco, CA, USA.
Howard LeongVeterans Affairs Medical Center, San Francisco, CA, USA.
Adriana M HungDivision of Nephrology and Hypertension, Vanderbilt University and Veterans Affairs Medical Center, Nashville, TN, USA.
Carl GrunfeldDepartment of Medicine, University of California, San Francisco, CA, USA.
Michael G ShlipakDepartment of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USSan Francisco VA Medical Center · USVanderbilt University Medical Center · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
CKD awareness and self-management: Interventions for Safety-Net PatientsK23DK094850 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TUOT, DELPHINE · 2012 to 2015
$754k
NCATS NIH HHS UL1 TR000004NIDDK NIH HHS K23 DK094850
6 · The paper itself

Abstract

aimsRecommendations for metformin use are dependent on eGFR category: eGFR >45 ml/min/1.73 m

methodsIn a consecutive cohort of 550 Veterans with diabetes, metformin use and eligibility were assessed by eGFR category, using eGFRcr and eGFRcys. Discrepancy in eligibility was defined as cases where eGFRcr and eGFRcys categories (<30, 30-44, 45-60, and >60 ml/min/1.73 m

resultsSubjects were 95% male, median age 68, and racially diverse (45% White, 22% Black, 11% Asian, 22% unknown). Metformin use decreased with severity of eGFRcr category, from 63% in eGFRcr >60 to 3% in eGFRcr <30. eGFRcys reclassified 20% of Veterans into different eGFR categories. Factors associated with a more severe eGFRcys category compared to eGFRcr were older age (aOR = 2.21 per decade, 1.44-1.82), higher BMI (aOR = 1.04 per kg/m

conclusionsMetformin use is low among Veterans with CKD. eGFRcys may serve as a confirmatory estimate of kidney function to allow safe use of metformin among patients with CKD, particularly among older individuals and those with albuminuria.

Indexed as

Chronic kidney diseaseCystatin CDiabetesMetformin

Identifiers

PMID28603691
PMCPMC5464411
OpenAlexW2224076229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.