Evidence map›Paper›PMID 28603687›Full record

ArticleNeuroImage. Clinical2017

Prematurity and brain perfusion: Arterial spin labeling MRI.

Domenico Tortora, Peter Angelo Mattei, Riccardo Navarra, Valentina Panara, Rita Salomone, Andrea Rossi, John A Detre, Massimo Caulo

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. White Matter Injury in Central Nervous System Disorders.Neuropsychiatric disease and treatment · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Domenico TortoraITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Neuroradiology Unit, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy. Electronic address: domenicotortora@gaslini.org.
Peter Angelo MatteiOphthalmology Clinic, Department of Medicine and Aging Sciences, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: pamattei@unich.it.
Riccardo NavarraITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: riccardo.navarra@unich.it.
Valentina PanaraITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: v.panara@rad.unich.it.
Rita SalomoneDepartment of Paediatrics, Neonatology and Neonatal Intensive Care Unit, University Hospital of Chieti, Via dei Vestini, 66100 Chieti, Italy. Electronic address: ritasalomone@tiscali.it.
Andrea RossiNeuroradiology Unit, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy. Electronic address: andrearossi@gaslini.org.
John A DetreDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: detre@mail.med.upenn.edu.
Massimo CauloITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: caulo@unich.it.

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
NIBIB NIH HHS P41 EB015893
6 · The paper itself

Abstract

purposeAbnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome was explored. MATERIALS AND

methodsThe institutional review board approved this prospective study and waived informed consent. The perfusion ASL data from 49 consecutive preterm neonates (PN) studied at term-equivalent age and 15 TN were evaluated. Statistically significant differences in gray matter CBF were evaluated by using a linear mixed-model analysis and Mann-Whitney

resultsComparison of means indicated that the CBF of the whole brain were significantly higher in PN compared to TN (

conclusionsASL MRI demonstrated differences in brain perfusion of the basal ganglia between PN and TN. In PN, a positive correlation between CBF and neuromotor outcome was demonstrated in this area.

Indexed as

Basal GangliaCerebrovascular CirculationFollow-Up StudiesHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesMagnetic Resonance ImagingSpin LabelsWhite MatterSpin LabelsASL, arterial spin labelingBrain perfusionCBF, cerebral blood flowHIE, hypoxic-ischemic encephalopathyNeonatePNp, preterm neonate periventricular white matter lesionsPN, preterm neonate with normal MRIPrematurityPVL, periventricular leukoencephalopathyTN, term neonate with normal MRI

Identifiers

PMID28603687
PMCPMC5454138

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.