Evidence map›Paper›PMID 28603670›Full record

ArticlePeerJ2017

The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of

Markéta Kostrouchová, David Kostrouch, Ahmed A Chughtai, Filip Kaššák, Jan P Novotný, Veronika Kostrouchová, Aleš Benda, Michael W Krause, Vladimír Saudek, Marta Kostrouchová and 1 more

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Markéta KostrouchováBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.
David KostrouchBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Ahmed A ChughtaiBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0002-9635-7463
Filip KaššákBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Jan P NovotnýBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0001-6021-0577
Veronika KostrouchováBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Aleš BendaImaging Methods Core Facility, BIOCEV, Faculty of Science, Charles University, Prague, Czech Republic.
Michael W KrauseLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Vladimír SaudekMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Marta KostrouchováBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Zdeněk KostrouchBiocev, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Charles University · CZNational Institutes of Health · USUniversity of Cambridge · GB

Funding

Developmental Gene Expression In C elegansZIADK036117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRAUSE, MICHAEL · 2014 to 2025
$9.3M
6 · The paper itself

Abstract

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate the influence of Mediator on RNA Polymerase II activity. One Mediator subunit, MED28, is known to interact with cytoplasmic structural proteins, providing a potential direct link between cytoplasmic dynamics and the control of gene transcription. Although identified in many animals and plants, MED28 is not present in yeast; no bona fide MED28 has been described previously in

Indexed as

Caenorhabditis elegansDevelopmentEvolutionGene expression regulationMED28Mediator complex

Identifiers

PMID28603670
PMCPMC5464003
OpenAlexW2558480315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.