Evidence map›Paper›PMID 28603621›Full record

ArticleJournal of materials chemistry. C2016

Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery.

Shawn He, George Tourkakis, Oleg Berezin, Nikolay Gerasimchuk, Hairong Zhang, Haying Zhou, Asaf Izraely, Walter J Akers, Mikhail Y Berezin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. C, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Shawn HeDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
George TourkakisDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Oleg BerezinMobichem Scientific Engineering, LTD, Israel.
Nikolay GerasimchukChemistry Department, Missouri State University, Springfield, MO, USA.
Hairong ZhangDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Haying ZhouDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Asaf IzraelyAlbaad Massuot Yitzhak Ltd, Israel.
Walter J AkersDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Mikhail Y BerezinDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · USAcademy of Arts, Architecture and Design in Prague · CZDeutsche Telekom (Austria) · ATMissouri State University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
MULTIMODAL PRECLINICAL CANCER IMAGING AND THERAPY RESEARCH SPECIALISTR50CA211481 · NCI · WASHINGTON UNIVERSITY · PI AKERS, WALTER JOHN · 2016 to 2020
$841k
FLUORESCENCE SPECTROPHOTOMETER IN NIR RANGE FOR BIOLOGICAL AND MEDICAL APPLICATIOS10RR031621 · NCRR · WASHINGTON UNIVERSITY · PI BEREZIN, MIKHAIL Y. · 2011 to 2011
$292k
NCI NIH HHS P30 CA091842NCI NIH HHS R50 CA211481NCRR NIH HHS S10 RR031621
6 · The paper itself

Abstract

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40°C to 60°C.

Identifiers

PMID28603621
PMCPMC5464001
OpenAlexW2285250966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.