Evidence map›Paper›PMID 28603578›Full record

ArticleCancer and clinical oncology2017

Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model.

Raluca A Budiu, Anda M Vlad, Linda Nazario, Chandra Bathula, Kristine L Cooper, Jessica Edmed, Premal H Thaker, Julie Urban, Pawel Kalinski, Adrian V Lee and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Cancer and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  7. Article
  8. Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Raluca A BudiuDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Anda M VladDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Linda NazarioMagee Womens Research Institute, Pittsburgh, PA, 15213, USA.
Chandra BathulaDepartment of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Kristine L CooperBiostatistics Facility Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Jessica EdmedUniversity of Brighton, School of Pharmacy & Biomolecular Sciences, Brighton, BN2 4GJ, UK.
Premal H ThakerDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University, St Louis, MO, 63110, USA.
Julie UrbanDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Pawel KalinskiDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Adrian V LeeDepartment of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Esther L ElishaevMagee Womens Research Institute, Pittsburgh, PA, 15213, USA.
Thomas P ConradsWomen's Health Integrated Research Center at Inova Health System, Annandale, VA, 22003, USA.
Melanie S FlintDepartment of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
University of Pittsburgh · USUPMC Hillman Cancer Center · USInova Health System · USMagee-Womens Research Institute · USUniversity of Brighton · GBWashington University in St. Louis · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Type-1 Antigen Presenting Cells in CNS Tumors - Key to Efficient Anti-Tumor T-CelP01CA132714 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KALINSKI, PAWEL · 2009 to 2013
$6.8M
MUC1 Roles in ovarian cancer pathogenesis and immune therapyR01CA163462 · NCI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI VLAD, ANDA M · 2012 to 2016
$1.4M
NCI NIH HHS P01 CA132714NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA163462
6 · The paper itself

Abstract

The ability of stress to induce immune suppression is widely recognized, but the mechanisms underlying the effects of stress on the adaptive immune system during tumor progression are not completely understood. To study the effect of stress on the immune system

Indexed as

breast cancersocial isolationstressT cellsTregs

Identifiers

PMID28603578
PMCPMC5464739
OpenAlexW2555282728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.