Evidence map›Paper›PMID 28603523›Full record

ArticleFrontiers in immunology2017

KIR3DS1-Mediated Recognition of HLA-*B51: Modulation of KIR3DS1 Responsiveness by Self HLA-B Allotypes and Effect on NK Cell Licensing.

Simona Carlomagno, Michela Falco, Maria Bono, Claudia Alicata, Lucia Garbarino, Michela Mazzocco, Lorenzo Moretta, Alessandro Moretta, Simona Sivori

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  9. Article
  10. Human NK cells, their receptors and function.European journal of immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Simona CarlomagnoDipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.
Michela FalcoIstituto Giannina Gaslini, Genova, Italy.
Maria BonoIstituto Giannina Gaslini, Genova, Italy.
Claudia AlicataDipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.
Lucia GarbarinoS.C. Laboratorio di Istocompatibilità e IBMDR, E.O. Ospedali Galliera, Genova, Italy.
Michela MazzoccoS.C. Laboratorio di Istocompatibilità e IBMDR, E.O. Ospedali Galliera, Genova, Italy.
Lorenzo MorettaDipartimento di Immunologia, IRCCS Ospedale Bambin Gesù, Roma, Italy.
Alessandro MorettaDipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.
Simona SivoriDipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.
University of Genoa · ITEnte Ospedaliero Ospedali Galliera · ITIstituto Giannina Gaslini · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies described an association between killer-cell immunoglobulin-like receptor (KIR)/HLA gene combinations and clinical outcomes in various diseases. In particular, an important combined role for KIR3DS1 and HLA-B Bw4-I80 in controlling viral infections and a higher protection against leukemic relapses in donor equipped with activating KIRs in haplo-HSCT has been described. Here, we show that KIR3DS1 mediates positive signals upon recognition of HLA-B*51 (Bw4-I80) surface molecules on target cells and that this activation occurs only in Bw4-I80

Indexed as

activating killer-immunoglobulin-like receptorsHLA-B alleleshuman natural killer cellsKIR3DS1KIR/KIR-L interactionnatural killer cell education

Identifiers

PMID28603523
PMCPMC5445109
OpenAlexW2617992695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.