ArticleFrontiers in cellular neuroscience2017
Corticostriatal Regulation of Acute Pain.
Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review.Frontiers in neurology · 2025Pooled it
- Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.The journal of headache and pain · 2026Article
- Dorsal root ganglion neuromodulation restores accumbal gate to inhibit mechanical allodynia.The journal of headache and pain · 2026Article
- Article
- Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Altered structure and functional connection of subcortical gray matter in female patients with classical trigeminal neuralgia.Brain imaging and behavior · 2024Article
- Neuropathic pain has sex-specific effects on oxycodone-seeking and non-drug-seeking ensemble neurons in the dorsomedial prefrontal cortex of mice.Addiction biology · 2024Article
- Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024Review
- rTMS and TENS Relieve Neuropathic Pain in CCI Model Rats by Modulating Central Nervous System TRPV1 and Neuroinflammation.Mediators of inflammation · 2024Article
- Disrupted Resting-State Functional Connectivity and Effective Connectivity of the Nucleus Accumbens in Chronic Low Back Pain: A Cross-Sectional Study.Journal of pain research · 2024Article
- Restoration of the Activity of the Prefrontal Cortex to the Nucleus Accumbens Core Pathway Relieves Fentanyl-Induced Hyperalgesia in Male Rats.Journal of pain research · 2024Article
- Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain.Neuron · 2023Article
- A prototype closed-loop brain-machine interface for the study and treatment of pain.Nature biomedical engineering · 2023Article
- Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Review
- Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex.Molecular brain · 2023Article
- Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.Frontiers in neuroscience · 2023Article
- Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents.Science translational medicine · 2022Article
- Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics.Neuroscience bulletin · 2022Review
- Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief.Molecular pain · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms for acute pain regulation in the brain are not well understood. The prefrontal cortex (PFC) provides top-down control of emotional processes, and it projects to the nucleus accumbens (NAc). This corticostriatal projection forms an important regulatory pathway within the brain's reward system. Recently, this projection has been suggested to control both sensory and affective phenotypes specifically associated with chronic pain. As this projection is also known to play a role in the transition from acute to chronic pain, we hypothesized that this corticostriatal circuit can also exert a modulatory function in the acute pain state. Here, we used optogenetics to specifically target the projection from the PFC to the NAc. We tested sensory pain behaviors with Hargreaves' test and mechanical allodynia, and aversive pain behaviors with conditioned place preference (CPP) test. We found that the activation of this corticostriatal circuit gave rise to bilateral relief from peripheral nociceptive inputs. Activation of this circuit also provided important control for the aversive response to transient noxious stimulations. Hence, our results support a novel role for corticostriatal circuitry in acute pain regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.