Evidence map›Paper›PMID 28603468›Full record

Trial reportJournal of the International Society of Sports Nutrition2017

Minimal dose of milk protein concentrate to enhance the anabolic signalling response to a single bout of resistance exercise; a randomised controlled trial.

Cameron J Mitchell, Nina Zeng, Randall F D'Souza, Sarah M Mitchell, Kirsten Aasen, Aaron C Fanning, Sally D Poppitt, David Cameron-Smith

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cameron J MitchellLiggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
Nina ZengLiggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
Randall F D'SouzaLiggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
Sarah M MitchellLiggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
Kirsten AasenLiggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
Aaron C FanningFonterra Research and Development Centre, Private Bag 11 029, Palmerston North, 4442 New Zealand.
Sally D PoppittSchool of Biological Sciences, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
David Cameron-SmithLiggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland, 1142 New Zealand.
University of Auckland · NZAuckland University of Technology · NZFonterra (New Zealand) · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResistance training is a potent stimulus to induce muscle hypertrophy. Supplemental protein intake is known to enhance gains in muscle mass through activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway, which initiates protein translation. While the optimal dose of high quality protein to promote post exercise anabolism in young or older men has been investigated, little is known about the minimum doses of protein required to potentiate the resistance exercise activation of anabolic signalling in middle aged men.

methodsTwenty healthy men (46.3 ± 5.7 years, BMI: 23.9 ± 6.6 kg/m

resultsP70S6K

conclusionsNine grams of milk protein is sufficient to augment some measures of downstream mTORC1 signalling after resistance exercise but does not potentiate exercise induced increases in amino acid transporter expression. Formulated products containing nine grams of milk protein would be expected stimulate muscle anabolism after resistance exercise.

trial registrationNew Zealand Clinical Trials Registry ACTRN12615001375549. Registered: 17 December, 2015.

Indexed as

Resistance TrainingAdultAmino Acid Transport System AAmino Acid Transport SystemsCationic Amino Acid Transporter 1Double-Blind MethodExerciseHumansLarge Neutral Amino Acid-Transporter 1MaleMechanistic Target of Rapamycin Complex 1Middle AgedMilk ProteinsPhosphorylationRibosomal Protein S6 Kinases, 70-kDaSymportersAmino Acid Transport System AAmino Acid Transport SystemsCationic Amino Acid Transporter 1Large Neutral Amino Acid-Transporter 1Mechanistic Target of Rapamycin Complex 1Milk ProteinsRibosomal Protein S6 Kinases, 70-kDaSLC36A1 protein, humanSLC38A2 protein, humanSLC7A1 protein, humanSymportersMiddle ageP70SKProtein phosphorylationSkeletal muscleSupplement

Identifiers

PMID28603468
PMCPMC5465465
OpenAlexW2623166876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.