Evidence map›Paper›PMID 28603409›Full record

ArticleClinical interventions in aging2017

Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients.

Natsalil Pongthanaracht, Somchai Yanarojana, Darawan Pinthong, Supeenun Unchern, Amnuay Thithapandha, Prasert Assantachai, Porntip Supavilai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Genetic polymorphism analysis of patients with primary hyperhidrosis.Clinical, cosmetic and investigational dermatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Natsalil PongthanarachtDepartment of Pharmacology, Faculty of Science.
Somchai YanarojanaDepartment of Pharmacology, Faculty of Science.
Darawan PinthongDepartment of Pharmacology, Faculty of Science.
Supeenun UnchernDepartment of Pharmacology, Faculty of Science.
Amnuay ThithapandhaDepartment of Pharmacology, Faculty of Science.
Prasert AssantachaiDepartment of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Porntip SupavilaiDepartment of Pharmacology, Faculty of Science.
Siriraj Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the association of the butyrylcholinesterase K variant (BChE-K) and the plasma BChE activity with mild cognitive impairment (MCI) in Thai community-dwelling patients.

methodsOne hundred patients diagnosed with MCI and 100 control subjects were recruited from the community-dwelling setting in Bangkok, Thailand. The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing. The BChE activity was measured in plasma according to the Ellman's method.

resultsThe BChE-K allele frequencies in the Thai community-dwelling patients were in accordance with other ethnics. The BChE-K allele frequency in the control subjects (12%) was higher than that of MCI patients (5.5%), suggesting a protective role of BChE-K for MCI in the Thai community-dwelling patients. The BChE-K homozygotes were significantly associated with lower BChE activity.

conclusionOur results suggested that the BChE-K may be implicated as a protective factor for MCI in the Thai community-dwelling patients, although a further study with a large sample size is warranted to confirm this.

Indexed as

AgedButyrylcholinesteraseCognitive DysfunctionFemaleGene FrequencyGenotypeHumansMaleMiddle AgedPolymerase Chain ReactionThailandButyrylcholinesterasebutyrylcholinesterase activitybutyrylcholinesterase K variantmild cognitive impairmentThai community-dwelling patients

Identifiers

PMID28603409
PMCPMC5457172
OpenAlexW2619034752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.