ArticleComputational mechanics2017
Modeling molecular mechanisms in the axon.
Article in Computational mechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.bioRxiv : the preprint server for biology · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.Frontiers in cell and developmental biology · 2024Article
- Cooperative melting in double-stranded peptide chains through local mechanical interactions.Journal of the Royal Society, Interface · 2023Article
- Unravelling the mechanotransduction pathways in Alzheimer's disease.Journal of biological engineering · 2023Review
- Image-based axon model highlights heterogeneity in initiation of damage.Biophysical journal · 2023Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Viscoelastic damage evaluation of the axon.Frontiers in bioengineering and biotechnology · 2022Article
- Geometrical nonlinear elasticity of axon under tension: A coarse-grained computational study.Biophysical journal · 2021Article
- Modeling links softening of myelin and spectrin scaffolds of axons after a concussion to increased vulnerability to repeated injuries.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation.Biophysical journal · 2018Article
- Damage and Failure of Axonal Microtubule under Extreme High Strain Rate: An In-Silico Molecular Dynamics Study.Scientific reports · 2018Article
- Microtubule Polymerization and Cross-Link Dynamics Explain Axonal Stiffness and Damage.Biophysical journal · 2018Article
- An Integrated Cytoskeletal Model of Neurite Outgrowth.Frontiers in cellular neuroscience · 2018Review
- Physical Biology of Axonal Damage.Frontiers in cellular neuroscience · 2018Article
- Neurite elongation is highly correlated with bulk forward translocation of microtubules.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Axons are living systems that display highly dynamic changes in stiffness, viscosity, and internal stress. However, the mechanistic origin of these phenomenological properties remains elusive. Here we establish a computational mechanics model that interprets cellular-level characteristics as emergent properties from molecular-level events. We create an axon model of discrete microtubules, which are connected to neighboring microtubules via discrete crosslinking mechanisms that obey a set of simple rules. We explore two types of mechanisms: passive and active crosslinking. Our passive and active simulations suggest that the stiffness and viscosity of the axon increase linearly with the crosslink density, and that both are highly sensitive to the crosslink detachment and reattachment times. Our model explains how active crosslinking with dynein motors generates internal stresses and actively drives axon elongation. We anticipate that our model will allow us to probe a wide variety of molecular phenomena-both in isolation and in interaction-to explore emergent cellular-level features under physiological and pathological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.