Evidence map›Paper›PMID 28603085›Full record

ArticleFree radical biology & medicine2017

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

Lucía Fernández-Del-Río, Anish Nag, Elena Gutiérrez Casado, Julia Ariza, Agape M Awad, Akil I Joseph, Ohyun Kwon, Eric Verdin, Rafael de Cabo, Claus Schneider and 4 more

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Understanding coenzyme Q.Physiological reviews · 2024
    Review
  3. Article
  4. Biosynthesis, Deficiency, and Supplementation of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  5. Identification of novel coenzyme QThe Journal of biological chemistry · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. How plants synthesize coenzyme Q.Plant communications · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Lucía Fernández-Del-RíoDepartamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Spain.
Anish NagDepartment of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Elena Gutiérrez CasadoDepartamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Spain.
Julia ArizaDepartamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Spain.
Agape M AwadDepartment of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Akil I JosephDepartment of Pharmacology, and the Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN, USA.
Ohyun KwonDepartment of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Eric VerdinBuck Institute for Research on Aging, Novato, CA, USA.
Rafael de CaboTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Claus SchneiderDepartment of Pharmacology, and the Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, TN, USA.
Jorge Z TorresDepartment of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
María I BurónDepartamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Spain.
Catherine F ClarkeDepartment of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
José M VillalbaDepartamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Spain.
University of Córdoba · ESVanderbilt University · USBuck Institute for Research on Aging · USNational Institutes of Health · US

Funding

Aging Intervention ProgramZIAAG000363 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$9.0M
Calorie restriction and agingZIAAG000368 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$6.9M
Phosphine-Catalyzed Annulations and Their ApplicationsR01GM071779 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OHYUN KWON · 2006 to 2026
$5.7M
Aging and CR effects on the Plasma Membrane Redox SystemZIAAG000362 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$5.0M
Oxidative activation of the dietary cancer chemopreventive agent curcuminR01AT006896 · NCCIH · VANDERBILT UNIVERSITY · PI SCHNEIDER, CLAUS · 2013 to 2017
$2.2M
NCCIH NIH HHS R01 AT006896NIGMS NIH HHS R01 GM071779
6 · The paper itself

Abstract

Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on dietary supplementation with Q

Indexed as

AnimalsAntioxidantsCarbon IsotopesCell LineEpithelial CellsFibroblastsHEK293 CellsHep G2 CellsHL-60 CellsHumansIsotope LabelingKaempferolsKidney Tubules, ProximalMiceMitochondriaPolyphenolsAntioxidantsCarbon IsotopeskaempferolKaempferolsPolyphenolsSIRT3 protein, humanSirtuin 3Ubiquinone4-hydroxybenzoic acidAntioxidantsCoenzyme QFlavonolsKaempferolKidney cellsPlant polyphenolsSirt3

Identifiers

PMID28603085
PMCPMC5539908
OpenAlexW2624028232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.