Evidence map›Paper›PMID 28603013›Full record

ArticleCellular signalling2017

Oxytocin (OXT)-stimulated inhibition of Kir7.1 activity is through PIP

Nathaniel York, Patrick Halbach, Michelle A Chiu, Ian M Bird, De-Ann M Pillers, Bikash R Pattnaik

Open access · greenAbstract read
In one paragraph

Article in Cellular signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  7. Article
  8. Inward rectifier potassium (Kir) channels in the retina: living our vision.American journal of physiology. Cell physiology · 2022
    Review
  9. Article
  10. Article
  11. Review
  12. Kir7.1 disease mutant T153I within the inner pore affects KAmerican journal of physiology. Cell physiology · 2022
    Article
  13. Article
  14. Review
  15. Retinal Development and Pathophysiology in Kcnj13 Knockout Mice.Frontiers in cell and developmental biology · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nathaniel YorkEndocrinology-Reproductive Physiology Program, The University of Wisconsin, Madison, WI 53715, United States; Division of Neonatology& Newborn Nursery, The University of Wisconsin, Madison, WI 53715, United States; Departments of Pediatrics, The University of Wisconsin, Madison, WI 53715, United States; The McPherson Eye Research Institute, The University of Wisconsin, Madison, WI 53715, United States.
Patrick HalbachEndocrinology-Reproductive Physiology Program, The University of Wisconsin, Madison, WI 53715, United States; Division of Neonatology& Newborn Nursery, The University of Wisconsin, Madison, WI 53715, United States; Departments of Pediatrics, The University of Wisconsin, Madison, WI 53715, United States; The McPherson Eye Research Institute, The University of Wisconsin, Madison, WI 53715, United States.
Michelle A ChiuDivision of Neonatology& Newborn Nursery, The University of Wisconsin, Madison, WI 53715, United States; Departments of Pediatrics, The University of Wisconsin, Madison, WI 53715, United States; The McPherson Eye Research Institute, The University of Wisconsin, Madison, WI 53715, United States.
Ian M BirdEndocrinology-Reproductive Physiology Program, The University of Wisconsin, Madison, WI 53715, United States; Obstetrics & Gynecology, The University of Wisconsin, Madison, WI 53715, United States.
De-Ann M PillersDivision of Neonatology& Newborn Nursery, The University of Wisconsin, Madison, WI 53715, United States; Departments of Pediatrics, The University of Wisconsin, Madison, WI 53715, United States; Medical Genetics, The University of Wisconsin, Madison, WI 53715, United States; The McPherson Eye Research Institute, The University of Wisconsin, Madison, WI 53715, United States.
Bikash R PattnaikEndocrinology-Reproductive Physiology Program, The University of Wisconsin, Madison, WI 53715, United States; Division of Neonatology& Newborn Nursery, The University of Wisconsin, Madison, WI 53715, United States; Departments of Pediatrics, The University of Wisconsin, Madison, WI 53715, United States; Ophthalmology &Visual Sciences, The University of Wisconsin, Madison, WI 53715, United States; The McPherson Eye Research Institute, The University of Wisconsin, Madison, WI 53715, United States. Electronic address: pattnaik@wisc.edu.
University of Wisconsin–Madison · US

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
Molecular Therapies for Lebers Congenital Amaurosis Caused by KCNJ13 MutationsR01EY024995 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PATTNAIK, BIKASH RANJAN · 2015 to 2018
$1.5M
NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY024995
6 · The paper itself

Abstract

Oxytocin (OXT) is a neuropeptide that activates the oxytocin receptor (OXTR), a rhodopsin family G-protein coupled receptor. Our localization of OXTR to the retinal pigment epithelium (RPE), in close proximity to OXT in the adjacent photoreceptor neurons, leads us to propose that OXT plays an important role in RPE-retinal communication. An increase of RPE [Ca

Indexed as

Signal TransductionAnimalsCalciumCell LineCells, CulturedHEK293 CellsHumansMice, Inbred C57BLOxytocinPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Inwardly RectifyingReceptors, OxytocinRetinal Pigment EpitheliumCalciumKir7.1 channelOxytocinPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Inwardly RectifyingReceptors, OxytocinCalcium imagingCell signalingHormone receptorInositol 1,4,5-trisphosphate (IP3)Ion-channelOxytocinOxytocin receptorRetinaRPE

Identifiers

PMID28603013
PMCPMC5554455
OpenAlexW2622196605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.