Evidence map›Paper›PMID 28603004›Full record

ArticleMechanisms of development2017

Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration.

Brandon M Franklin, S Randal Voss, Jeffrey L Osborn

Open access · greenAbstract read
In one paragraph

Article in Mechanisms of development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Inter-organ communication during tissue regeneration.Development (Cambridge, England) · 2023
    Review
  6. Article
  7. Article
  8. MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Biomedical applications of electrical stimulation.Cellular and molecular life sciences : CMLS · 2020
    Review
  13. Article
  14. Review
  15. Review
  16. Amputation-induced reactive oxygen species signaling is required for axolotl tail regeneration.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brandon M FranklinDepartment of Biology, University of Kentucky, Lexington, KY 40506, United States.
S Randal VossDepartment of Biology, University of Kentucky, Lexington, KY 40506, United States.
Jeffrey L OsbornDepartment of Biology, University of Kentucky, Lexington, KY 40506, United States. Electronic address: jlosbo3@uky.edu.
University of Kentucky · US

Funding

Ambystoma Genetic Stock Center - Revision to Include Curation and Informatics ComponentP40OD019794 · OD · UNIVERSITY OF KENTUCKY · PI Stephen Randal Voss · 2015 to 2026
$6.3M
Developing Regeneration Resources for a Model AmphibianR24OD021479 · OD · UNIVERSITY OF KENTUCKY · PI THORSON, JON SCOTT, VOSS, STEPHEN RANDAL · 2016 to 2019
$2.3M
NIH HHS P40 OD019794NIH HHS R24 OD021479
6 · The paper itself

Abstract

Little is known about the potential for ion channels to regulate cellular behaviors during tissue regeneration. Here, we utilized an amphibian tail regeneration assay coupled with a chemical genetic screen to identify ion channel antagonists that altered critical cellular processes during regeneration. Inhibition of multiple ion channels either partially (anoctamin1/Tmem16a, anoctamin2/Tmem16b, K

Indexed as

Ambystoma mexicanumAnimalsCell ProliferationIon ChannelsPhagocytesRegenerationSignal TransductionTailIon Channels

Identifiers

PMID28603004
PMCPMC6386162
OpenAlexW2621685105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.