ArticleFungal genetics and biology : FG & B2017
Species boundaries in the human pathogen Paracoccidioides.
Article in Fungal genetics and biology : FG & B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
142 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genetic background and immune response in paracoccidioidomycosis: A systematic review and meta-analysis of single nucleotide variants.PLoS neglected tropical diseases · 2026Pooled it
- Talaromyces marneffei, Coccidioides species, and Paracoccidioides species-a systematic review to inform the World Health Organization priority list of fungal pathogens.Medical mycology · 2024Pooled it
- Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.Mycopathologia · 2023Pooled it
- Name Changes for Fungi of Medical Importance, 2016-2017.Journal of clinical microbiology · 2019Pooled it
- FDG-PET/CT Demonstrates Superior Detection of Multiorgan Involvement in Paracoccidioidomycosis Compared With Conventional Staging.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Collagen depletion, not keloid formation, defines lobomycosis lesions: a paired skin analysis.Medical mycology case reports · 2026Article
- Paracoccidioidomycosis in the 21st century: Challenges and milestones.PLoS neglected tropical diseases · 2026Review
- Combined anti-PD-1 and amphotericin B therapy reduces fungal burden and enhances control of murine paracoccidioidomycosis.Frontiers in cellular and infection microbiology · 2026Article
- Mitochondrial genomic variation, evolutionary dynamics, and phylogeny of forest-associatedIMA fungus · 2026Article
- Telomeric assemblies ofbioRxiv : the preprint server for biology · 2025Article
- Unraveling the Nano World in Paracoccidioidomycosis: Promising Applications of Nanotechnology in Diagnosis, Treatment, and Vaccines: A Mini Review.Current microbiology · 2025Review
- Article
- IL-6 Degradation by Secreted Proteases FromInternational journal of microbiology · 2025Article
- Cecal appendicitis as a rare manifestation of paracoccidioidomycosis: A case report and systematic review of the literature.The journal of venomous animals and toxins including tropical diseases · 2025Article
- Article
- Extracellular vesicles from virulentVirulence · 2024Article
- Comparison between PCR-RFLP and sequencing techniques in the analysis of Paracoccidioides spp. biodiversity: limitations and insights into species and variant differentiation.Mycopathologia · 2024Article
- Admixture in the fungal pathogen Blastomyces.Genetics · 2024Article
- Diagnosis of Human Endemic Mycoses Caused by Thermally Dimorphic Fungi: From Classical to Molecular Methods.Journal of fungi (Basel, Switzerland) · 2024Review
- Paracoccidioides lutzii Infects Galleria mellonella Employing Formamidase as a Virulence Factor.PLoS neglected tropical diseases · 2024Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The use of molecular taxonomy for identifying recently diverged species has transformed the study of speciation in fungi. The pathogenic fungus Paracoccidioides spp has been hypothesized to be composed of five phylogenetic species, four of which compose the brasiliensis species complex. Nuclear gene genealogies support this divergence scenario, but mitochondrial loci do not; while all species from the brasiliensis complex are differentiated at nuclear coding loci, they are not at mitochondrial loci. We addressed the source of this incongruity using 11 previously published gene fragments, 10 newly-sequenced nuclear non-coding loci, and 10 microsatellites. We hypothesized and further demonstrated that the mito-nuclear incongruence in the brasiliensis species complex results from interspecific hybridization and mitochondrial introgression, a common phenomenon in eukaryotes. Additional population genetic analyses revealed possible nuclear introgression but much less than that seen in the mitochondrion. Our results are consistent with a divergence scenario of secondary contact and subsequent mitochondrial introgression despite the continued persistence of species boundaries. We also suggest that yeast morphology slightly-but significantly-differs across all five Paracoccidioides species and propose to elevate four of these phylogenetic species to formally described taxonomic species.
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Registered trials
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