Evidence map›Paper›PMID 28602817›Full record

ArticleNeuroImage2017

On memories, neural ensembles and mental flexibility.

Dimitris A Pinotsis, Scott L Brincat, Earl K Miller

Abstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Ephaptic coupling and power fluctuations in depression.bioRxiv : the preprint server for biology · 2025
    Article
  3. In vivo ephaptic coupling allows memory network formation.Cerebral cortex (New York, N.Y. : 1991) · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dimitris A PinotsisThe Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Wellcome Trust Centre for Neuroimaging, University College London, WC1N 3BG, UK. Electronic address: pinotsis@mit.edu.
Scott L BrincatThe Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Earl K MillerThe Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Funding

Cortical Circuits for Attention and DecisionsR37MH087027 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MILLER, EARL K · 2010 to 2019
$4.7M
NIMH NIH HHS R37 MH087027
6 · The paper itself

Abstract

Memories are assumed to be represented by groups of co-activated neurons, called neural ensembles. Describing ensembles is a challenge: complexity of the underlying micro-circuitry is immense. Current approaches use a piecemeal fashion, focusing on single neurons and employing local measures like pairwise correlations. We introduce an alternative approach that identifies ensembles and describes the effective connectivity between them in a holistic fashion. It also links the oscillatory frequencies observed in ensembles with the spatial scales at which activity is expressed. Using unsupervised learning, biophysical modeling and graph theory, we analyze multi-electrode LFPs from frontal cortex during a spatial delayed response task. We find distinct ensembles for different cues and more parsimonious connectivity for cues on the horizontal axis, which may explain the oblique effect in psychophysics. Our approach paves the way for biophysical models with learned parameters that can guide future Brain Computer Interface development.

Indexed as

CuesModels, TheoreticalAnimalsBiophysicsBrain WavesElectrocorticographyFrontal LobeMacaca fascicularisMacaca mulattaMaleMemory, Short-TermNerve NetSaccadesSpace PerceptionUnsupervised Machine LearningVisual PerceptionAuto-encodersBetweenness centralityCharacteristic path lengthEffective connectivityMemory engramsNeural ensemblesNeural field theoryWorking memory

Identifiers

PMID28602817
PMCPMC5600840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.