Evidence map›Paper›PMID 28602816›Full record

ArticleNeuroImage2017

Neurobiological correlates of impulsivity in healthy adults: Lower prefrontal gray matter volume and spontaneous eye-blink rate but greater resting-state functional connectivity in basal ganglia-thalamo-cortical circuitry.

Cole Korponay, Daniela Dentico, Tammi Kral, Martina Ly, Ayla Kruis, Robin Goldman, Antoine Lutz, Richard J Davidson

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Associations of brain structure with psychopathy.European archives of psychiatry and clinical neuroscience · 2026
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  11. Relations of gray matter volume to dimensional measures of cognition and affect in mood disorders.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Article
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  13. The effect of learning to drum on behavior and brain function in autistic adolescents.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  15. Article
  16. The role of prefrontal cortex in cognitive control and executive function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  17. Article
  18. Article
  19. Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Cole KorponayDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA. Electronic address: ckorponay@wisc.edu.
Daniela DenticoDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: dentico@wisc.edu.
Tammi KralDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: kral@wisc.edu.
Martina LyCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: mly@wisc.edu.
Ayla KruisCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA; University of Amsterdam, 1012 WX Amsterdam, Netherlands. Electronic address: a.kruis@uva.nl.
Robin GoldmanCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: rigoldman@wisc.edu.
Antoine LutzLyon Neuroscience Research Center, Brain Dynamics and Cognition Team, INSERM U1028, CNRS UMR5292, Lyon 1 University, Lyon, France; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: antoine.lutz@inserm.fr.
Richard J DavidsonDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA; Department of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: rjdavids@wisc.edu.
University of Wisconsin–Madison · USCentre National de la Recherche Scientifique · FRUniversity of Amsterdam · NL

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
Wisconsin Center for the Neuroscience and Psychophysiology of MeditationP01AT004952 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 2008 to 2018
$14.7M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
STRESS EXPOSURE, HPA ACTIVITY AND RISK FOR ADOLESCENT INTERNALIZING DISORDERSP50MH084051 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2008 to 2012
$9.6M
Neural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6M
NCCIH NIH HHS P01 AT004952NICHD NIH HHS P30 HD003352NIMH NIH HHS P50 MH084051NIMH NIH HHS R01 MH043454NIMH NIH HHS T32 MH018931
6 · The paper itself

Abstract

Studies consistently implicate aberrance of the brain's reward-processing and decision-making networks in disorders featuring high levels of impulsivity, such as attention-deficit hyperactivity disorder, substance use disorder, and psychopathy. However, less is known about the neurobiological determinants of individual differences in impulsivity in the general population. In this study of 105 healthy adults, we examined relationships between impulsivity and three neurobiological metrics - gray matter volume, resting-state functional connectivity, and spontaneous eye-blink rate, a physiological indicator of central dopaminergic activity. Impulsivity was measured both by performance on a task of behavioral inhibition (go/no-go task) and by self-ratings of attentional, motor, and non-planning impulsivity using the Barratt Impulsiveness Scale (BIS-11). Overall, we found that less gray matter in medial orbitofrontal cortex and paracingulate gyrus, greater resting-state functional connectivity between nodes of the basal ganglia-thalamo-cortical network, and lower spontaneous eye-blink rate were associated with greater impulsivity. Specifically, less prefrontal gray matter was associated with higher BIS-11 motor and non-planning impulsivity scores, but was not related to task performance; greater correlated resting-state functional connectivity between the basal ganglia and thalamus, motor cortices, and prefrontal cortex was associated with worse no-go trial accuracy on the task and with higher BIS-11 motor impulsivity scores; lower spontaneous eye-blink rate was associated with worse no-go trial accuracy and with higher BIS-11 motor impulsivity scores. These data provide evidence that individual differences in impulsivity in the general population are related to variability in multiple neurobiological metrics in the brain's reward-processing and decision-making networks.

Indexed as

Inhibition, PsychologicalAdultBasal GangliaBlinkingConnectomeFemaleGray MatterHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMiddle AgedMotor CortexPrefrontal CortexPsychomotor PerformanceThalamusBasal gangliaGray matter volumeHealthy adultsImpulsivityPrefrontal cortexResting-state functional connectivitySpontaneous eye-blink rate

Identifiers

PMID28602816
PMCPMC5600835
OpenAlexW2623520015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.