Evidence map›Paper›PMID 28602616›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age.

Alexandre Casimiro de Macedo, José Evandro Cunha, Juliana Navarro Ueda Yaochite, Clodis Maria Tavares, Aparecida Tiemi Nagao-Dias

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Serum IgA Antibodies Specific toFrontiers in medicine · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexandre Casimiro de MacedoUniversidade Federal do Ceará (UFC), Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brazil.
José Evandro CunhaUniversidade Federal do Ceará (UFC), Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brazil.
Juliana Navarro Ueda YaochiteUniversidade Federal do Ceará (UFC), Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brazil.
Clodis Maria TavaresUniversidade Federal de Alagoas, Faculdade de Enfermagem e Farmácia (ESENFAR), Maceio, AL, Brazil.
Aparecida Tiemi Nagao-DiasUniversidade Federal do Ceará (UFC), Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brazil. Electronic address: anagaodias@gmail.com.
Universidade Federal do Ceará · BRUniversidade Federal de Alagoas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.

Indexed as

Contact TracingFamilyAdolescentAntibodies, BacterialAntigens, BacterialChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleGlycolipidsHumansLeprosy, MultibacillaryLeprosy, PaucibacillaryMaleMycobacterium lepraeSalivaAntibodies, BacterialAntigens, BacterialGlycolipidsphenolic glycolipid I, Mycobacterium lepraeLeprosyMycobacterium lepraePhenolic glycolipid-1 antigenSalivary antibodies

Identifiers

PMID28602616
PMCPMC9425475
OpenAlexW2623183671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.