Evidence map›Paper›PMID 28602477›Full record

ReviewFertility and sterility2017

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why.

Bruce A Lessey, J Julie Kim

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fertility and sterility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 6 pooled it
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 6 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Expression ofInternational journal of molecular sciences · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Review
  10. Review
  11. Review
  12. Observational
  13. Review
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Diagnosis and management of endometriosis-associated infertility Number 4 - 2026.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026
    Article
  19. Article
  20. Review

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Bruce A LesseyDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Greenville Health System, Greenville, South Carolina. Electronic address: blessey@ghs.org.
J Julie KimDivision of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.
Northwestern University · USPrisma Health · US

Funding

Progesterone Action in the Endometrium of Women with EndometriosisR01HD067721 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, STEVEN L · 2011 to 2015
$3.1M
NICHD NIH HHS R01 HD067721
6 · The paper itself

Abstract

The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation creates the opportunity in the setting of endometriosis for establishment of chronic inflammation that is disruptive to endometrial receptivity, causing both infertility and abnormal bleeding. Clinically, there can be little doubt that the endometrium of women with endometriosis is less receptive to embryo implantation, and strong evidence exists to suggest that endometrial changes are associated with decreased cycle fecundity as a result of this disease. Here we provide unifying concepts regarding those changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis.

Indexed as

AnimalsEmbryo ImplantationEmbryo TransferEndometriosisEndometriumEvidence-Based MedicineFemaleFertilization in VitroHumansInfertility, FemaleMenstrual CycleModels, ImmunologicalPregnancyRecurrenceSpecies SpecificityTranscriptomeendometrial receptivityEndometriosisendometriumimplantationprogesterone resistance

Identifiers

PMID28602477
PMCPMC5629018
OpenAlexW2624413373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.