ArticleAtherosclerosis2017
Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification.
Abstract readMulticenter Study
In one paragraph
Article in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Changes in vascular structure and function in primary hyperparathyroidism: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies.Arteriosclerosis, thrombosis, and vascular biology · 2024Pooled it
- Structural Carotid Atherosclerosis and Mild Behavioral Impairment: A Cross-Sectional Study in a Community-Dwelling Population.The Kaohsiung journal of medical sciences · 2026Article
- Role of Arterial Stiffness and Carotid Intima-Media Thickness on Subclinical Atherosclerosis and Cardiovascular Risk Assessment.Cardiology and therapy · 2025Review
- Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Enhancing Cardiovascular Risk Prediction with a Simplified Carotid IMT Protocol: Evidence from the IMPROVE Study.Biomedicines · 2025Article
- Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population.Cardiovascular diabetology · 2025Article
- Machine learning-based prediction of carotid intima-media thickness progression: a three-year prospective cohort study.Frontiers in medicine · 2025Article
- Saudi Heart Association Position Statement on Early Detection of Subclinical Atherosclerosis in Clinical Practice.Journal of the Saudi Heart Association · 2025Article
- Quantitative correlation between carotid or lower limb atherosclerosis and coronary heart disease: a retrospective observational study.Frontiers in endocrinology · 2025Observational
- Unseen threat: how subclinical atherosclerosis increases mortality risk in patients with type 1 diabetes.Cardiovascular diabetology · 2024Observational
- Association between eating speed and atherosclerosis in relation to growth differentiation factor-15 levels in older individuals in a cross-sectional study.Scientific reports · 2024Article
- Predictability of Cardiovascular Risk Scores for Carotid Atherosclerosis in Community-Dwelling Middle-Aged and Elderly Adults.Journal of clinical medicine · 2024Article
- Noninvasive carotid ultrasound for predicting vulnerable plaques of the coronary artery based on optical coherence tomography images.Quantitative imaging in medicine and surgery · 2024Article
- Association of severely damaged endodontically infected tooth with carotid plaque and abnormal carotid intima-media thickness: a retrospective analysis.Clinical oral investigations · 2023Article
- Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study.Circulation. Genomic and precision medicine · 2023Article
- Preliminary study of carotid variables under ultrasound analysis as predictors for the risk of coronary arterial atherosclerosis.Echocardiography (Mount Kisco, N.Y.) · 2022Article
- Evaluation of Intima-Media Thickness and Arterial Stiffness as Early Ultrasound Biomarkers of Carotid Artery Atherosclerosis.Cardiology and therapy · 2022Review
- Complications of Diabetes and Metrics of Glycemic Management Derived From Continuous Glucose Monitoring.The Journal of clinical endocrinology and metabolism · 2022Review
- Association of traditional risk factors with carotid intima-media thickness and carotid plaque in asymptomatic individuals with a family history of premature cardiovascular disease.The international journal of cardiovascular imaging · 2022Article
Corrections and comments
- Commented on by
Authors and funding
19 authors.
Mauro AmatoCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.
Philippe GiralAssistance Publique - Hopitaux de Paris, Service Endocrinologie-Metabolisme, Groupe Hôpitalier Pitie-Salpetriere, Unités de Prévention Cardiovasculaire, Paris, France.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Andries J SmitDepartment of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sudhir KurlInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Finland.
Alessio RavaniCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Beatrice FrigerioCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Daniela SansaroCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Alice BonomiCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Calogero C TedescoCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Samuela CastelnuovoCentro Dislipidemie E. Grossi Paoletti, Ospedale Ca' Granda di Niguarda, Milan, Italy.
Elmo MannarinoInternal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
Steve E HumphriesCardiovascular Genetics, British Heart Foundation Laboratories, Institute Cardiovascular Science, University College of London, Rayne Building, London, United Kingdom.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Elena TremoliCentro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Damiano BaldassarreCentro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Medical Biotechnology and Translational Medicine, Università di Milano, Milan, Italy. Electronic address: damiano.baldassarre@unimi.it.
IMPROVE study group
Funding
British Heart Foundation RG/08/008/25291
Abstract
BACKGROUND AND
aimsCarotid plaque size and the mean common carotid intima-media thickness measured in plaque-free areas (PF CC-IMT
methodsThe IMPROVE-study is a European cohort (n = 3703), where the thickness of the largest plaque detected in the whole carotid tree was indexed as cIMT
resultsAfter a 36.2-month follow-up, there were 215 VEs (125 coronary, 73 cerebral and 17 peripheral). Both cIMT
conclusionscIMT
Indexed as
Carotid Intima-Media ThicknessPlaque, AtheroscleroticAgedCarotid Artery, CommonCarotid Artery DiseasesCerebrovascular DisordersCoronary DiseaseEuropeFemaleHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMonte Carlo MethodPeripheral Arterial DiseaseAtherosclerosisCardiovascular clinical researchCardiovascular risk factorsCarotid intima-media thicknessCoronary artery diseasePrevention
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.