ArticleJournal of Ayurveda and integrative medicine
Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Evaluation ofJMIR research protocols · 2026Article
- Framework for evidence synthesis of traditional, complementary and integrative medicine systems incorporating context and complexity, illustrated by the example of homeopathy.Frontiers in public health · 2026Article
- Effectiveness of Ayush Rasayana A and B on the Quality of Life of Older Adults: Protocol for a Cluster Randomized Controlled Trial.JMIR research protocols · 2024Article
- Potential Antiaging Effects of DLBS1649, aJournal of experimental pharmacology · 2021Article
- The Microbiome in Health and Disease from the Perspective of Modern Medicine and Ayurveda.Medicina (Kaunas, Lithuania) · 2020Review
- Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs.Journal of clinical medicine · 2020Article
- Geroprotection through modulation of heart rate variability, oxidative enzymes, tissue integrity, and gene expression by an Ayurvedic herbal formulation, Amalaki Rasayana.Journal of Ayurveda and integrative medicineArticle
- Promoting evidence-base for Ayurveda.Journal of Ayurveda and integrative medicineArticle
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity.
objectiveIn the present study, we investigated telomerase activity and telomere length in the peripheral blood mononuclear cells of aged individuals administered with Amalaki Rasayana. MATERIALS AND
methodsAmalaki Rasayana was administered to healthy, aged (45-60 years) volunteers for 45 days after koshta shuddhi procedure. The telomerase activity and telomere length were analyzed on 0, 45th and 90th days of Amalaki Rasayana administration in peripheral blood mononuclear cells from these individuals and compared with age-matched placebo group and young volunteers (22-30 years). The data were compared between the groups.
resultsThe results indicated an increase in telomerase activity with no discernible change in telomere length in the Amalaki administered participants. The comparison between young and aged participants revealed higher telomerase activity in young participants with no significant differences in telomere length.
conclusionThe data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing.
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