Evidence map›Paper›PMID 28602220›Full record

ArticleThe Journal of surgical research2017

Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2

Chad Hall, Laurent Ehrlich, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Terry C Lairmore, Gianfranco Alpini, Shannon Glaser

Open access · greenAbstract read
In one paragraph

Article in The Journal of surgical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Dichotomous Roles ofInternational journal of molecular sciences · 2022
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Diagnosis and Therapeutic Management of Liver Fibrosis by MicroRNA.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Article
  10. Pathobiology of biliary epithelia.Biochimica et biophysica acta. Molecular basis of disease · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Chad HallDepartment of Surgery, Baylor Scott & White Health and Texas A&M University Health Science Center, Temple, Texas.
Laurent EhrlichDepartment of Surgery, Baylor Scott & White Health and Texas A&M University Health Science Center, Temple, Texas; Department of Medicine, Baylor Scott & White Health and Texas A&M University Health Science Center, Temple, Texas.
Fanyin MengBaylor Scott & White Digestive Disease Research Center, Baylor Scott & White, Temple, Texas.
Pietro InvernizziCenter for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy.
Francesca BernuzziCenter for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy.
Terry C LairmoreDepartment of Surgery, Baylor Scott & White Health and Texas A&M University Health Science Center, Temple, Texas.
Gianfranco AlpiniDepartment of Medicine, Baylor Scott & White Health and Texas A&M University Health Science Center, Temple, Texas; Baylor Scott & White Digestive Disease Research Center, Baylor Scott & White, Temple, Texas; Research, Central Texas Veterans Health Care System, Temple, Texas.
Shannon GlaserDepartment of Medicine, Baylor Scott & White Health and Texas A&M University Health Science Center, Temple, Texas; Baylor Scott & White Digestive Disease Research Center, Baylor Scott & White, Temple, Texas; Research, Central Texas Veterans Health Care System, Temple, Texas. Electronic address: sglaser@medicine.tamhsc.edu.
Baylor Scott & White Health · USHumanitas University · ITBaylor Scott & White Medical Center - Temple · US

Funding

GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8M
Regulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9M
Role of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8M
TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSISR01DK058411 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CHERTOW, GLENN MATTHEW · 2001 to 2003
$1.8M
The Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7M
REGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435k
RESEARCH TRAINING IN SURGICAL GASTROENTEROLOGYT32DK007698 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MULHOLLAND, MICHAEL W. · 1994 to 2003
$335k
Role of Mechanosensitive Receptors During Biliary Proliferation and FibrosisI01BX002192 · VA · OLIN TEAGUE VETERANS CENTER · PI GLASER, SHANNON STROUD · 2014 to 2018
–
Functional characters of non-coding RNAs in alcoholic liver injuryI01BX001724 · VA · RLR VA MEDICAL CENTER · PI MENG, FANYIN · 2012 to 2024
–
Autocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–
BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX002192NIAAA NIH HHS R21 AA025997NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK058411NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS T32 DK007698
6 · The paper itself

Abstract

backgroundLiver transplantation remains the primary treatment for primary sclerosing cholangitis (PSC). Mdr2 MATERIALS AND

methodsMenin expression was measured in human PSC and Mdr2

resultsMenin gene expression was increased in Mdr2

conclusionsInhibition of miR-24 increases menin and TGF-β1 expression, subsequently increasing hepatic fibrosis in FVB/NJ WT and Mdr2

Indexed as

AnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCell LineCholangitis, SclerosingGene ExpressionHumansLiver CirrhosisMiceMice, KnockoutMicroRNAsProto-Oncogene ProteinsTransforming Growth Factor beta1ATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BMEN1 protein, humanMen1 protein, mouseMicroRNAsMirn24 microRNA, mouseProto-Oncogene ProteinsTgfb1 protein, mouseTransforming Growth Factor beta1Hepatic fibrosisLiverMeninmiR-24

Identifiers

PMID28602220
PMCPMC5760243
OpenAlexW2612765168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.