Evidence map›Paper›PMID 28601974›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2017

Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy.

Giovanni Forte, Beatrice Bocca, Riccardo Oggiano, Simonetta Clemente, Yolande Asara, Maria Alessandra Sotgiu, Cristiano Farace, Andrea Montella, Alessandro Giuseppe Fois, Michele Malaguarnera and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. An overview on amyotrophic lateral sclerosis and cadmium.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  8. Article
  9. The potential roles of aquaporin 4 in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Review
  10. Review
  11. News on the journal Neurological Sciences in 2017.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Giovanni ForteDepartment of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Beatrice BoccaDepartment of Environment and Health, Istituto Superiore di Sanità, Rome, Italy. beatrice.bocca@iss.it.ORCID http://orcid.org/0000-0002-6503-6026
Riccardo OggianoDepartment of Biomedical Sciences-Histology, University of Sassari, Sassari, Italy.
Simonetta ClementeMacomer Rehabilitation Center, Macomer, Sassari, Italy.
Yolande AsaraDepartment of Biomedical Sciences-Histology, University of Sassari, Sassari, Italy.
Maria Alessandra SotgiuDepartment of Biomedical Sciences-Histology, University of Sassari, Sassari, Italy.
Cristiano FaraceDepartment of Biomedical Sciences-Histology, University of Sassari, Sassari, Italy.
Andrea MontellaDepartment of Biomedical Sciences-Histology, University of Sassari, Sassari, Italy.
Alessandro Giuseppe FoisDepartment of Clinical and Experimental Medicine, Institute of Respiratory Diseases, University of Sassari, Sassari, Italy.
Michele MalaguarneraDepartment of Medical and Pediatric Science, Research Centre "The Great Senescence", University of Catania, Catania, Italy.
Pietro PirinaDepartment of Clinical and Experimental Medicine, Institute of Respiratory Diseases, University of Sassari, Sassari, Italy.
Roberto MadedduDepartment of Biomedical Sciences-Histology, University of Sassari, Sassari, Italy.
University of Sassari · ITIstituto Superiore di Sanità · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sardinian (Italy) island population has a uniquely high incidence of amyotrophic lateral sclerosis (ALS). Essential trace element levels in blood, hair, and urine of ALS Sardinian patients were investigated in search of valid biomarkers to recognize and predict ALS. Six elements (Ca, Cu, Fe, Mg, Se, and Zn) were measured in 34 patients compared to 30 age- and sex-matched healthy controls by a validated method. Levels of Ca and Cu in blood and of Se and Zn in hair were significantly higher in ALS than in controls, while urinary excretion of Mg and Se was significantly decreased. The selected cut-off concentrations for these biomarkers may distinguish patients with or without ALS with sufficient sensitivity and specificity. Many positive (as Se-Cu and Se-Zn) and negative associations (as Ca-Mg and Ca-Zn) between elements suggested that multiple metals involved in multiple mechanisms have a role in the ALS degeneration.

Indexed as

Age FactorsAmyotrophic Lateral SclerosisBiomarkersDisease ProgressionFemaleHairHumansItalyMaleMass SpectrometryMiddle AgedRiskROC CurveTrace ElementsBiomarkersTrace ElementsAmyotrophic lateral sclerosisBiomarkersBloodHairTrace elementsUrine

Identifiers

PMID28601974
OpenAlexW2622881939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.