Evidence map›Paper›PMID 28601963›Full record

ArticleEuropean journal of clinical pharmacology2017

Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population.

Marie Herr, Nicolas Sirven, Hélène Grondin, Sylvain Pichetti, Catherine Sermet

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In one paragraph

Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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  17. Characteristics of Japanese Older Adults Whose Trunk Muscle Mass Decreased during the COVID-19 Pandemic.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Marie HerrUMR 1168, Vieillissement et Maladies Chroniques : Approches Epidémiologique et de Santé Publique, INSERM and Université Versailles St-Quentin-en-Yvelines, Villejuif & Montigny-le-Bretonneux, France. marie.herr@uvsq.fr.
Nicolas SirvenInstitut de Recherche et Documentation en Economie de la Santé (IRDES), Paris, France.
Hélène GrondinUMR 1168, Vieillissement et Maladies Chroniques : Approches Epidémiologique et de Santé Publique, INSERM and Université Versailles St-Quentin-en-Yvelines, Villejuif & Montigny-le-Bretonneux, France.
Sylvain PichettiInstitut de Recherche et Documentation en Economie de la Santé (IRDES), Paris, France.
Catherine SermetInstitut de Recherche et Documentation en Economie de la Santé (IRDES), Paris, France.
Institut de Recherche et de Documentation en Économie de la Santé · FRInserm · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study analyses the relationship between medication use and frailty by considering the quantity of medications prescribed (polypharmacy) and the quality of medication prescribing (according to French criteria for Potentially Inappropriate Medications-PIMs) in people aged 65 and over.

methodsThis is a cross-sectional study based on the data from a nationally representative study about health and use of healthcare resources in France (ESPS 2012). The number of frailty criteria was assessed among exhaustion, unintentional weight loss, muscle weakness, impaired mobility, and low level of physical activity. Polypharmacy and PIMs were assessed from the data of reimbursement by the National Health Insurance over the whole year 2012. PIMs were defined according to the Laroche list plus additional criteria dealing with inappropriate prolonged use of medications. The analyses used Poisson regression models, with the number of frailty criteria as dependent variable.

resultsThe study population was composed of 1003 women and 887 men, of mean age 74.7 +/- 7.4 years. Polypharmacy (5 to 9 drugs) and excessive polypharmacy (≥10 drugs) were reported in 42.9 and 27.4% of the study population, respectively, while 46.7% of the study population received at least one PIM during the year 2012. Polypharmacy and PIMs were both associated with the number of frailty criteria in models adjusted for socio-demographic and health characteristics of the participants. The prescription of anticholinergic medications was the only PIM that remained significantly associated with the number of frailty criteria after adjustment for polypharmacy.

conclusionsPolypharmacy and use of anticholinergic medications are independently associated with frailty in old people.

Indexed as

PolypharmacyAgedAged, 80 and overCholinergic AntagonistsFemaleFrailtyFranceHumansInappropriate PrescribingMaleNational Health ProgramsCholinergic AntagonistsAgedAnticholinergic medicationsFrailtyInappropriate prescribingPolypharmacy

Identifiers

PMID28601963
OpenAlexW2622807049

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.