Evidence map›Paper›PMID 28601955›Full record

ArticleLipids2017

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation.

Mari Iwase, Takayuki Yamamoto, Kanako Nishimura, Haruya Takahashi, Shinsuke Mohri, Yongjia Li, Huei-Fen Jheng, Wataru Nomura, Nobuyuki Takahashi, Chu-Sook Kim and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Lipids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Frontiers in pharmacology · 2023
    Article
  4. Coumarins of Lovage Roots (Metabolites · 2022
    Article
  5. Article
  6. Phenolic Compounds of Propolis Alleviate Lipid Metabolism Disorder.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Mari IwaseLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Takayuki YamamotoLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Kanako NishimuraLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Haruya TakahashiLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Shinsuke MohriLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Yongjia LiLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Huei-Fen JhengLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Wataru NomuraLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Nobuyuki TakahashiLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Chu-Sook KimDepartment of Food Science and Nutrition, University of Ulsan, Ulsan, 680-749, South Korea.
Rina YuDepartment of Food Science and Nutrition, University of Ulsan, Ulsan, 680-749, South Korea.
Masahiko TaniguchiDepartment of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, 569-1094, Japan.
Kimiye BabaDepartment of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, 569-1094, Japan.
Shigeru MurakamiDepartment of Bioscience, Fukui Prefectural University, Fukui, 910-1195, Japan.
Teruo KawadaLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Tsuyoshi GotoLaboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan. tgoto@kais.kyoto-u.ac.jp.
Kyoto University · JPOsaka University of Pharmaceutical Sciences · JPUlsan College · KRFukui Prefectural University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the Apiaceae herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the Apiaceae family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic adipokine. We also demonstrated that suksdorfin activates peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipogenesis. Furthermore, we showed metabolic disorders in obese diabetic KK-A

Indexed as

3T3-L1 CellsAdipocytesAdiponectinAnimalsApiaceaeCell DifferentiationCoumarinsEnzyme ActivationGene Expression Regulation, EnzymologicGlucose Metabolism DisordersMiceMice, ObesePPAR gammaSignal TransductionAdiponectinAdipoq protein, mouseCoumarinsPPAR gammasuksdorfinAdipocyte differentiationCoumarinGlucose metabolismPPARγ

Identifiers

PMID28601955
OpenAlexW2621837851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.