Evidence map›Paper›PMID 28601835›Full record

ArticleBMJ open2017

Cohort profile: the Right to Care Clinical HIV Cohort, South Africa.

Matthew P Fox, Mhairi Maskew, Alana T Brennan, Denise Evans, Dorina Onoya, Given Malete, Patrick MacPhail, Jean Bassett, Osman Ebrahim, Dikeledi Mabotja and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Matthew P FoxDepartment of Global Health, Boston University School of Public Health, , Boston , , Massachusetts, , USA.
Mhairi MaskewDepartment of Medicine, Faculty of Health Sciences, Health Economics and Epidemiology Research Office, University of the Witwatersrand, , Johannesburg , , South Africa.
Alana T BrennanDepartment of Global Health, Boston University School of Public Health, , Boston , , Massachusetts, , USA.
Denise EvansDepartment of Medicine, Faculty of Health Sciences, Health Economics and Epidemiology Research Office, University of the Witwatersrand, , Johannesburg , , South Africa.
Dorina OnoyaDepartment of Medicine, Faculty of Health Sciences, Health Economics and Epidemiology Research Office, University of the Witwatersrand, , Johannesburg , , South Africa.
Given MaleteDepartment of Medicine, Faculty of Health Sciences, Health Economics and Epidemiology Research Office, University of the Witwatersrand, , Johannesburg , , South Africa.
Patrick MacPhailRight to Care, , Johannesburg , , South Africa.
Jean BassettWitkoppen Health and Welfare Centre, , Johannesburg , , South Africa.
Osman EbrahimOsman Clinic, , Johannesburg , , South Africa.
Dikeledi MabotjaThuthukani Clinic, , Johannesburg , , South Africa.
Sello MashamaiteRight to Care, , Johannesburg , , South Africa.
Lawrence LongDepartment of Medicine, Faculty of Health Sciences, Health Economics and Epidemiology Research Office, University of the Witwatersrand, , Johannesburg , , South Africa.
Ian SanneDepartment of Medicine, Clinical HIV Research Unit, University of the Witwatersrand, , Johannesburg , , South Africa.
University of the Witwatersrand · ZABoston University · USJohannesburg Hospital · ZARight to Care · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe research objectives of the Right to Care Clinical HIV Cohort analyses are to: (1) monitor treatment outcomes (including death, loss to follow-up, viral suppression and CD4 count gain among others) for patients on antiretroviral therapy (ART); (2) evaluate the impact of changes in the national treatment guidelines around when to initiate ART on HIV treatment outcomes; (3) evaluate the impact of changes in the national treatment guidelines around what ART regimens to initiate on drug switches; (4) evaluate the cost and cost-effectiveness of HIV treatment delivery models; (5) evaluate the need for and outcomes on second-line and third-line ART; (6) evaluate the impact of comorbidity with non-communicable diseases on HIV treatment outcomes and (7) evaluate the impact of the switch to initiating all patients onto ART regardless of CD4 count.

participantsThe Right to Care Clinical HIV Cohort is an open cohort of data from 10 clinics in two provinces within South Africa. All clinics include data from 2004 onwards. The cohort currently has data on over 115 000 patients initiated on HIV treatment and patients are followed up every 3-6 months for clinical and laboratory monitoring. FINDINGS TO DATE: Cohort data includes information on demographics, clinical visit, laboratory data, medication history and clinical diagnoses. The data have been used to identify rates and predictors of first-line failure, to identify predictors of mortality for patients on second-line (eg, low CD4 counts) and to show that adolescents and young adults are at increased risk of unsuppressed viral loads compared with adults. FUTURE PLANS: Future analyses will inform national models of HIV care and treatment to improve HIV care policy in South Africa.

Indexed as

AdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountCohort StudiesComorbidityCost-Benefit AnalysisDrug Administration ScheduleHIV InfectionsHumansMaleSouth AfricaViral LoadYoung AdultAnti-HIV AgentsHIV & AIDSINFECTIOUS DISEASESretention

Identifiers

PMID28601835
PMCPMC5724130
OpenAlexW2622950545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.