ArticleThe Journal of allergy and clinical immunology2018
Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis.
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Early life antibiotics and childhood gastrointestinal disorders: a systematic review.BMJ paediatrics open · 2021Pooled it
- Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes.The Journal of allergy and clinical immunology · 2021Pooled it
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
- A nationwide experience of biological treatments in children with eosinophilic esophagitis.Pediatric research · 2025Article
- Current and Emerging Therapies for Eosinophilic Esophagitis (EoE): A Comprehensive Review.Pharmaceutics · 2025Review
- Eosinophilic Esophagitis: Prevalence, Diagnosis, and Treatment in Childhood and Adulthood.Deutsches Arzteblatt international · 2025Review
- Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis.Children (Basel, Switzerland) · 2025Article
- Eosinophilic Esophagitis: real-life outcomes over 10 years in a Canadian pediatric centre.Frontiers in pediatrics · 2025Article
- Perinatal Environmental Risks for Eosinophilic Esophagitis: A Systemic Review and Meta-Analysis.Cureus · 2024Review
- Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis.Immunology and allergy clinics of North America · 2024Review
- Review article: Emerging insights into the epidemiology, pathophysiology, diagnostic and therapeutic aspects of eosinophilic oesophagitis and other eosinophilic gastrointestinal diseases.Alimentary pharmacology & therapeutics · 2024Review
- Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis.Przeglad gastroenterologiczny · 2024Review
- Barrier Dysfunction in Eosinophilic Esophagitis.Current gastroenterology reports · 2023Review
- Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- A Practical Update on Pediatric Eosinophilic Esophagitis.Children (Basel, Switzerland) · 2023Review
- Early life exposures as risk factors for non-esophageal eosinophilic gastrointestinal diseases.Clinics and research in hepatology and gastroenterology · 2023Article
- Impact of environmental factors on the epidemiology of eosinophilic esophagitis in southwestern Europe (2007-2020).The journal of allergy and clinical immunology. Global · 2023Article
- Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2023Review
- Eosinophilic Gastrointestinal Diseases: The Pathogenesis, Diagnosis, and Treatment.Internal medicine (Tokyo, Japan) · 2023Article
- Food allergy: cause or consequence of pediatric eosinophilic esophagitis? Potential implications of ultraprocessed foods in prevention and management.Frontiers in allergy · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMultiple lines of evidence point to the potential importance of early-life environmental factors in the rapid increase in the incidence of eosinophilic esophagitis (EoE), but potential exposures have not been extensively studied.
objectiveWe sought to assess the association between prenatal, intrapartum, and postnatal factors and the development of pediatric EoE using a case-control study.
methodsPatients with EoE were recruited from an existing registry at Cincinnati Children's Hospital Medical Center (CCHMC). Population-based community control subjects were identified from a separate CCHMC registry. Mothers of study subjects were contacted and completed a Web-based questionnaire. Crude and adjusted models were used to estimate associations.
resultsMothers of 127 cases and 121 control subjects were included. We observed a positive association between several early-life factors and EoE, including prenatal (maternal fever: adjusted odds ratio [aOR], 3.18; 95% CI, 1.27-7.98; preterm labor: aOR, 2.18; 95% CI, 1.06-4.48), intrapartum (cesarean delivery: aOR, 1.77; 95% CI, 1.01, 3.09), and infancy (antibiotic use: aOR, 2.30; 95% CI, 1.21-4.38; use of an acid suppressant: aOR, 6.05; 95% CI, 2.55-14.40) factors. We observed an inverse association between having a furry pet in infancy and EoE (aOR, 0.58; 95% CI, 0.34-0.97). No associations were observed for breast-feeding or maternal multivitamin or folic acid supplement use.
conclusionEarly-life factors, including maternal fever, preterm labor, cesarean delivery, and antibiotic or acid suppressant use in infancy, were associated with risk of pediatric EoE; having a pet in the home was protective. These results add to growing evidence that implicate early-life exposures in EoE pathogenesis.
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